The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
A repair system for 8-Oxo-7,8-dihydrodeoxyguanine
Abstract
Active oxygen species can damage DNA and may play a role in aging and carcinogenesis. We have tested MutY glycosylase for activity on undamaged mispairs as well as mispairs formed with the oxidatively damaged substrates, 8-oxo-7,8-dihydrodeoxyguanine (GO) or 8-oxo-7,8-dihydrodeoxyadenine (AO). MutY acts as a glycosylase on four of the heteroduplexes tested, A/G, A/GO, A/C, and A/AO, removing the undamaged adenine from each substrate. Genetic data suggest that the primary substrate for MutY glycosylase in vivo is the A/GO mispair. We present biochemical evidence demonstrating that MutY glycosylase is an important part of a repair system that includes the MutM and MutT proteins. The GO repair system is dedicated to the repair of the oxidatively damaged guanine and the mutations it can induce.
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Citations
Cites
Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG
Shibutani, S., Takeshita, M., & Grollman, A. P. (1991) · Nature · doi:10.1038/349431a0 · Cited by 2,224
Self-citation
Cited by
Role of oxygen radicals in DNA damage and cancer incidence
Valko, M., Izakovic, M., Mazur, M., Rhodes, C. J., & Telser, J. (2004) · Molecular and Cellular Biochemistry · doi:10.1023/b:mcbi.0000049134.69131.89 · Cited by 1,820
Mutagenesis by 8-oxoguanine: an enemy within
Grollman, A. P., & Moriya, M. (1993) · Trends in Genetics · doi:10.1016/0168-9525(93)90089-z · Cited by 807
Self-citationBrunk, E., & Rothlisberger, U. (2015) · Chemical Reviews · doi:10.1021/cr500628b · Cited by 494
Mutagenicity and repair of oxidative DNA damage: insights from studies using defined lesions
Wang, D., Kreutzer, D. A., & Essigmann, J. M. (1998) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(98)00066-9 · Cited by 464
Increased oxidative damage to DNA in ALS patients
Bogdanov, M., Brown, R. H., Matson, W., Smart, R., Hayden, D., O’Donnell, H., Flint Beal, M., & Cudkowicz, M. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00349-x · Cited by 334
Metadata
- Authors
- Michaels, M. L., Tchou, J., Grollman, A. P., & Miller, J. H.
- Venue
- Biochemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 1992-11-01
- Volume
- 31
- Issue
- 45
- Pages
- 10964-10968
- ISSN
- 0006-2960 (ISSN-L)
- 1520-4995
- OpenAlex
- W2037184450
- Cited by
- 309
- References
- 1
- FWCI
- 3.05
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: A repair system for 8-Oxo-7,8-dihydrodeoxyguanine. https://app.cochat.ai/papers/10.1021/bi00160a004
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- Michaels, M. L., Tchou, J., Grollman, A. P., & Miller, J. H. (1992). A repair system for 8-Oxo-7,8-dihydrodeoxyguanine. Biochemistry. https://doi.org/10.1021/bi00160a004
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
