The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Reevaluation of interaction of cis-dichloro(ethylenediamine)platinum(II) with DNA
Abstract
Intrastrand cross-links represent the majority of modifications in DNA resulting from interaction with the cancer chemotherapeutic drug cis-diamminedichloroplatinum(II) (cis-DDP). These adducts were recently characterized although several discrepancies remained to be resolved. In these studies, [3H]-cis-dichloro(ethylenediamine)platinum(II) (cis-DEP) was used because of the convenience of the radiolabel; this analogue produces adducts at identical sites in DNA as cis-DDP. Both drugs platinate the following sequences in DNA: GG, 65%; AG, 25%; GNG, 6%. The adduct at AG sequences invariably has adenine on the 5'-terminus of the dimer. The present enzyme digestion protocol included P1 nuclease, which produced complete digestion rather than as previously reported. The frequency of platination at GG was too high to be explained by an initial monofunctional platination at any guanine. However, direct bifunctional attack preferentially at GG was obviated because monofunctional adducts could be trapped with thiourea at short time periods. After short incubations, with cis-DEP and removal of unreacted drug, the monofunctional adducts slowly rearranged to bifunctional adducts. It is suggested that this evolution of adducts may result from the drug "walking" along the double helix, a phenomenon that does not appear to occur in single-stranded DNA.
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Fichtinger-Schepman, A. M. J., Van der Veer, J. L., Den Hartog, J. H. J., Lohman, P. H. M., & Reedijk, J. (1985) · Biochemistry · doi:10.1021/bi00324a025 · Cited by 1,024
The Mechanism of Action of Antitumor Platinum Compounds
Roberts, J. J., & Thomson, A. J. (1979) · Progress in Nucleic Acid Research and Molecular Biology · doi:10.1016/s0079-6603(08)60799-0 · Cited by 411
Royer‐Pokora, B., Gordon, L. K., & Haseltine, W. A. (1981) · Nucleic Acids Research · doi:10.1093/nar/9.18.4595 · Cited by 144
Eastman, A. R. (1985) · Biochemistry · doi:10.1021/bi00340a011 · Cited by 142
Self-citationTullius, T. D., & Lippard, S. J. (1981) · Journal of the American Chemical Society · doi:10.1021/ja00405a073 · Cited by 90
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Ajima, K., Yudasaka, M., Murakami, T., Maigné, A., Shiba, K., & Iijima, S. (2005) · Molecular Pharmaceutics · doi:10.1021/mp0500566 · Cited by 411
Crystal Structure of the Anticancer Drug Cisplatin Bound to Duplex DNA
Takahara, P. M., Frederick, C. A., & Lippard, S. J. (1996) · Journal of the American Chemical Society · doi:10.1021/ja9625079 · Cited by 405
Cellular and molecular determinants of cisplatin resistance
Perez, R. P. (1998) · European Journal of Cancer · doi:10.1016/s0959-8049(98)00227-5 · Cited by 384
Cisplatin Binding Sites on Human Albumin
Ivanov, A. I., Christodoulou, J., Parkinson, J. A., Barnham, K. J., Tucker, A., Woodrow, J., & Sadler, P. J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.24.14721 · Cited by 362
Inhibition of RNA polymerase II as a trigger for the p53 response
Ljungman, M., Zhang, F., Chen, F., Rainbow, A. J., & McKay, B. C. (1999) · Oncogene · doi:10.1038/sj.onc.1202356 · Cited by 288
Metadata
- Authors
- Eastman, A.
- Venue
- Biochemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 1986-07-01
- Volume
- 25
- Issue
- 13
- Pages
- 3912-3915
- ISSN
- 0006-2960 (ISSN-L)
- 1520-4995
- OpenAlex
- W1976874431
- Cited by
- 458
- References
- 5
- FWCI
- 8.00
- Type
- journal article
- Language
- en
- Open access
- closed
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- Eastman, A. (1986). Reevaluation of interaction of cis-dichloro(ethylenediamine)platinum(II) with DNA. Biochemistry. https://doi.org/10.1021/bi00361a026
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