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Mechanism of inhibition of DNA gyrase by quinolone antibacterials: a cooperative drug-DNA binding model
Abstract
We have proposed a cooperative quinolone-DNA binding model for the inhibition of DNA gyrase. The essential feature of the model is that bound gyrase induces a specific quinolone binding site in the relaxed DNA substrate in the presence of ATP. The binding affinity and specificity are derived from two unique and equally important functional features: the specific conformation of the proposed single-stranded DNA pocket induced by the enzyme and the unique self-association phenomenon (from which the cooperativity is derived) of the drug molecules to fit the binding pocket with a high degree of flexibility. Supporting evidence for and implications of this model are provided.
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Citations
Cited by
DNA gyrase, topoisomerase IV, and the 4-quinolones.
Drlica, K., & Zhao, X. (1997) · Microbiology and molecular biology reviews : MMBR · doi:10.1128/.61.3.377-392.1997 · Cited by 1,494
Bacterial Topoisomerase Inhibitors: Quinolone and Pyridone Antibacterial Agents
Mitscher, L. A. (2005) · Chemical Reviews · doi:10.1021/cr030101q · Cited by 781
Self-citationThe interactions of metal ions with quinolone antibacterial agents
Turel, I. (2002) · Coordination Chemistry Reviews · doi:10.1016/s0010-8545(02)00027-9 · Cited by 572
Paul, T., Dodd, M. C., & Strathmann, T. J. (2010) · Water Research · doi:10.1016/j.watres.2010.03.002 · Cited by 368
Structural insight into the quinolone–DNA cleavage complex of type IIA topoisomerases
Laponogov, I., Sohi, M. K., Veselkov, D. A., Pan, X.-S., Sawhney, R., Thompson, A. W., McAuley, K. E., Fisher, L. M., & Sanderson, M. R. (2009) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1604 · Cited by 304
Metadata
- Authors
- Shen, L. L., Mitscher, L. A., Sharma, P. N., O'Donnell, T. J., Chu, D. W. T., Cooper, C. S., Rosen, T., & Pernet, A. G.
- Venue
- Biochemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 1989-05-02
- Volume
- 28
- Issue
- 9
- Pages
- 3886-3894
- ISSN
- 0006-2960 (ISSN-L)
- 1520-4995
- OpenAlex
- W2052467184
- Cited by
- 413
- References
- 0
- FWCI
- 5.58
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Mechanism of inhibition of DNA gyrase by quinolone antibacterials: a cooperative drug-DNA binding model. https://app.cochat.ai/papers/10.1021/bi00435a039
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- Shen, L. L., Mitscher, L. A., Sharma, P. N., O'Donnell, T. J., Chu, D. W. T., Cooper, C. S., Rosen, T., & Pernet, A. G. (1989). Mechanism of inhibition of DNA gyrase by quinolone antibacterials: a cooperative drug-DNA binding model. Biochemistry. https://doi.org/10.1021/bi00435a039
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
