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Membrane protein folding and oligomerization: the two-stage model
Abstract
We discuss the view that the folding of many, perhaps most, integral membrane proteins can be considered as a two-stage process. In stage I, hydrophobic alpha-helices are established across the lipid bilayer. In stage II, they interact to form functional transmembrane structures. This model is suggested by the nature of transmembrane segments in known structures, refolding experiments, the assembly of integral membrane protein from fragments, and the existence of very small integral membrane protein subunits. It may extend to proteins with a variety of functions, including the formation of transmembrane aqueous channels. The model is discussed in the context of the forces involved in membrane protein folding and the interpretation of sequence data.
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Citations
Cited by
MEMBRANE PROTEIN FOLDING AND STABILITY: Physical Principles
White, S. H., & Wimley, W. C. (1999) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.28.1.319 · Cited by 1,764
The GxxxG motif: A framework for transmembrane helix-helix association
Russ, W. P., & Engelman, D. M. (2000) · Journal of Molecular Biology · doi:10.1006/jmbi.1999.3489 · Cited by 936
Self-citationFolding of helical membrane proteins: the role of polar, GxxxG-like and proline motifs
Senes, A., Engel, D. E., & DeGrado, W. F. (2004) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2004.07.007 · Cited by 434
TOXCAT: A measure of transmembrane helix association in a biological membrane
Russ, W. P., & Engelman, D. M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.3.863 · Cited by 347
Self-citationA dimerization motif for transmembrane α–helices
Lemmon, M. A., Treutlein, H. R., Adams, P. D., Brünger, A. T., & Engelman, D. M. (1994) · Nature Structural Biology · doi:10.1038/nsb0394-157 · Cited by 314
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Metadata
- Authors
- Popot, J. L., & Engelman, D. M.
- Venue
- Biochemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 1990-05-01
- Volume
- 29
- Issue
- 17
- Pages
- 4031-4037
- ISSN
- 0006-2960 (ISSN-L)
- 1520-4995
- OpenAlex
- W2027711565
- Cited by
- 932
- References
- 0
- FWCI
- 7.43
- Type
- journal article
- Language
- en
- Open access
- closed
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- Popot, J. L., & Engelman, D. M. (1990). Membrane protein folding and oligomerization: the two-stage model. Biochemistry. https://doi.org/10.1021/bi00469a001
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
