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Magnesium-induced self-association of calf brain tubulin. I. Stoichiometry
Abstract
The self-association of calf brain tubulin at pH 7.0 in the presence of magnesium ions has been examined by velocity sedimentation. The schlieren patterns were analyzed by methods described by Gilbert and by Cox. The observed process is best described in terms of a rapidly reversible progressive self-association of the tubulin dimer with identical chain elongation equilibrium constants, k, terminated by a ring-closing step, at degree of polymerization n = 26 +/- 2, with k26 greater than k. The end product of the polymerization reaction has a sedimentation coefficient s20,w0 k2 +/- 2 S. It is hydrodynamically equivalent to a closed ring structure observed in the electron microscope at identical conditions.
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Citations
Cited by
In vitro reconstitution of calf brain microtubules: effects of solution variables
Lee, J. C., & Timasheff, S. N. (1977) · Biochemistry · doi:10.1021/bi00627a037 · Cited by 332
Self-citationHamel, E. (2003) · Cell Biochemistry and Biophysics · doi:10.1385/cbb:38:1:1 · Cited by 272
Regulation of rabbit muscle phosphofructokinase by phosphorylation
Cai, G.-Z., Callaci, T. P., Luther, M. A., & Ching Lee, J. (1997) · Biophysical Chemistry · doi:10.1016/s0301-4622(96)02232-6 · Cited by 31
Metadata
- Authors
- Frigon, R. P., & Timasheff, S. N.
- Venue
- Biochemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 1975-10-01
- Volume
- 14
- Issue
- 21
- Pages
- 4559-4566
- ISSN
- 0006-2960 (ISSN-L)
- 1520-4995
- OpenAlex
- W2033790849
- Cited by
- 173
- References
- 0
- FWCI
- 5.47
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Magnesium-induced self-association of calf brain tubulin. I. Stoichiometry. https://app.cochat.ai/papers/10.1021/bi00692a001
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- Frigon, R. P., & Timasheff, S. N. (1975). Magnesium-induced self-association of calf brain tubulin. I. Stoichiometry. Biochemistry. https://doi.org/10.1021/bi00692a001
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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