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Novel Processing of β-Amyloid Precursor Protein Catalyzed by Membrane Type 1 Matrix Metalloproteinase Releases a Fragment Lacking the Inhibitor Domain against Gelatinase A

Higashi, Shouichi, Miyazaki, Kaoru·2003·Biochemistry
DOI 10.1021/bi020643m
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Abstract

In various mammalian cell lines, beta-amyloid precursor protein (APP) is proteolytically processed to release its NH(2)-terminal extracellular domain as a soluble APP (sAPP) that contains the inhibitor domain against gelatinase A. To investigate roles of sAPP in the regulation of gelatinase A activity, we examined the correlation between the activation of progelatinase A and processing of APP. We found that stimulation of HT1080 fibrosarcoma cells with concanavalin A led to an activation of endogenous progelatinase A and to a novel processing of APP, which releases a COOH-terminally truncated form of sAPP (sAPPtrc) into the culture medium. Reverse zymographic analysis showed that sAPPtrc lacked an inhibitory activity against gelatinase A. Analyses of production of sAPPtrc in the presence of various metalloproteinase inhibitors showed that membrane type 1 matrix metalloproteinase (MT1-MMP), an activator of progelatinase A, is most likely responsible for the production of sAPPtrc. When the concanavalin A-stimulated HT1080 cells were cultured in the condition that inhibited MT1-MMP activity, sAPP and APP were associated with the extracellular matrix deposited by the cells, whereas these gelatinase A inhibitors in the matrix were displaced by sAPPtrc after exertion of MT1-MMP activity. Taken together, these data support a model in which MT1-MMP-catalyzed release of sAPPtrc leads to reduction of the extracellular matrix-associated gelatinase A inhibitor, sAPP, thus making it feasi…

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Research works printed but not linked: 53

  1. Kang J., 1987, Nature 325, 733−736
  2. Sisodia S. S., 1990, Science 248, 492−495
  3. Esch F. S., 1990, Science 248, 1122−1124
  4. Arribas J., 1996, J. Biol. Chem., 271, 10.1074/jbc.271.19.11376 · DOI
  5. Arribas J., 1997, J. Biol. Chem., 272, 10.1074/jbc.272.27.17160 · DOI
  6. Buxbaum J. D., 1998, J. Biol. Chem., 273, 10.1074/jbc.273.43.27765 · DOI
  7. Palmert M. R., 1989, Proc. Natl. Acad. Sci. U.S.A. 86, 6338−6342
  8. Podlisny M. B., 1990, Biochem. Biophys. Res. Commun. 167, 1094−1101
  9. Smith R. P., 1990, Science 248, 1126−1128
  10. Miyata S., 1999, J. Biochem. (Tokyo), 125, 10.1093/oxfordjournals.jbchem.a022388 · DOI
  11. Schubert D., 1989, Neuron 3, 689−694
  12. Chen M., 1991, Neurosci. Lett., 125, 10.1016/0304-3940(91)90034-Q · DOI
  13. Small D. H., 1994, J. Neurosci., 14, 10.1523/JNEUROSCI.14-04-02117.1994 · DOI
  14. Jin L. W., 1994, J. Neurosci., 14
  15. Mattson M. P., 1993, Neuron 10, 243−254
  16. Miyazaki K., 1993, Nature 362, 839−841
  17. Small D. H., 1992, J. Neurosci., 12
  18. Caceres J., 1997, J. Cell. Biochem., 65, 10.1002/(SICI)1097-4644(199705)65:2<145::AID-JCB2>3.0.CO;2-U · DOI
  19. Kibbey M. C., 1993, Proc. Natl. Acad. Sci. U.S.A. 90, 10150−10153
  20. Beher D., 1996, J. Biol. Chem., 271, 10.1074/jbc.271.3.1613 · DOI
  21. Ohsawa I., 2001, J. Neurochem., 76, 10.1046/j.1471-4159.2001.00144.x · DOI
  22. Docherty A. J. P., 1992, Trends Biotechnol. 10, 200−207
  23. Matrisian L. M., 1992, Bioessays 14, 455−463
  24. Stetler-Stevenson W. G., 1993, Annu. Rev. Cell Biol., 9, 10.1146/annurev.cb.09.110193.002545 · DOI
  25. Liotta L. A., 1986, Cancer Res., 46, 7
  26. Collier I. E., 1988, J. Biol. Chem., 263
  27. Wilhelm S. M., 1989, J. Biol. Chem., 264, 10.1016/S0021-9258(18)71480-4 · DOI
  28. Brooks P. C., 1998, Cell 92, 391−400
  29. Sato H., 1994, Nature, 370, 65, 10.1038/370061a0 · DOI
  30. Pei D., 1999, J. Biol. Chem., 274
  31. Pei D., 1999, Cell Res. 9, 291−303
  32. Yana I., 2002, Clin. Exp. Metastasis 19, 209−215
  33. Strongin A. Y., 1995, J. Biol. Chem., 270, 10.1074/jbc.270.10.5331 · DOI
  34. Higashi S., 1999, J. Biol. Chem., 274, 10.1074/jbc.274.15.10497 · DOI
  35. Miyazaki K., 1993, J. Biol. Chem., 268, 10.1016/S0021-9258(19)85251-1 · DOI
  36. Miyazaki K., 1990, Cancer Res. 50, 7758−7764
  37. Koshikawa N., 1996, J. Biochem. (Tokyo), 119, 10.1093/oxfordjournals.jbchem.a021244 · DOI
  38. Overall C. M., 1990, J. Biol. Chem., 265, 10.1016/S0021-9258(17)45338-5 · DOI
  39. Griffith M. J., 1982, J. Biol. Chem., 257
  40. Pratt C. W., 1992, J. Biol. Chem., 267
  41. Segel, I. H. (1975) Enzyme Kinetics, pp 320−329, Wiley-Interscience, New York.
  42. Howard E. W., 1991, J. Biol. Chem., 266
  43. Olson M. W., 1997, J. Biol. Chem., 272
  44. Will H., 1996, J. Biol. Chem., 271, 10.1074/jbc.271.29.17119 · DOI
  45. Zucker S., 1998, J. Biol. Chem., 273, 10.1074/jbc.273.2.1216 · DOI
  46. Stanton H., 1998, J. Cell Sci., 111, 10.1242/jcs.111.18.2789 · DOI
  47. Shofuda K., 1998, J. Biochem. (Tokyo), 124, 10.1093/oxfordjournals.jbchem.a022136 · DOI
  48. Nakahara H., 1997, Proc. Natl. Acad. Sci. U.S.A. 94, 7959−7964
  49. Murphy G., 1992, Biochem. J., 283
  50. Van Nostrand W. E., 1991, Biochem. Biophys. Res. Commun., 175, 21, 10.1016/S0006-291X(05)81193-3 · DOI
  51. Hernandez-Barrantes S., 2000, J. Biol. Chem., 275, 10.1074/jbc.275.16.12080 · DOI
  52. Higashi S., 2003, J. Biol. Chem., 278
  53. Abbreviations APP, β-amyloid precursor protein

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Metadata

Authors
Higashi, S., & Miyazaki, K.
Venue
Biochemistry
Publisher
American Chemical Society (ACS)
Published
2003-05-08
Volume
42
Issue
21
Pages
6514-6526
ISSN
  • 0006-2960
  • 1520-4995
DOI
10.1021/bi020643m
Cited by
53
References
0
Language
en

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