Mechanism of antiandrogen action: key role of Hsp90 in conformational change and transcriptional activity of the androgen receptor.

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2. Studies of Targeting and Intracellular Trafficking of an Anti-Androgen Doxorubicin−Formaldehyde Conjugate in PC-3 Prostate Cancer Cells Bearing Androgen Receptor-GFP Chimera
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3. SWATH-MS Based Proteomic Profiling of Prostate Cancer Cells Reveals Adaptive Molecular Mechanisms in Response to Anti-Androgen Therapy
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4. Inhibition of Hsp90 Augments Docetaxel Therapy in Castrate Resistant Prostate Cancer
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5. Heat Shock Protein 90: The Cancer Chaperone
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6. Gene Targeting to the Stroma of the Prostate and Bone
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7. Mutation of the Androgen Receptor at Amino Acid 708 (Gly→Ala) Abolishes Partial Agonist Activity of Steroidal Antiandrogens
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8. Mechanisms of Sex Disparities in Cardiovascular Function and Remodeling
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9. Enzalutamide-induced Proteolytic Degradation of the Androgen Receptor in Prostate Cancer Cells Is Mediated Only to a Limited Extent by the Proteasome System
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10. Novel AR/AR-V7 and Mnk1/2 Degrader, VNPP433-3β: Molecular Mechanisms of Action and Efficacy in AR-Overexpressing Castration Resistant Prostate Cancer In Vitro and In Vivo Models
    Elizabeth B. Thomas, Retheesh S. Thankan, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas P. Ambulos, David J. Weber, Vincent C.O. Njar · 2022 · Cells
11. Developing New Treatment Options for Castration-Resistant Prostate Cancer and Recurrent Disease
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12. Differential proteome expression analysis of androgen-dependent and -independent pathways in LNCaP prostate cancer cells
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13. A new mutation of the androgen receptor, P817A, causing partial androgen insensitivity syndrome: in vitro and structural analysis
    Serge Lumbroso, Alexandre Wagschal, William Bourguet, Virginie Georget, Inas Mazen, Nadège Servant, Françoise Audran, Charles Sultan, Gilles Auzou · 2004 · Journal of Molecular Endocrinology
14. Improving selective androgen receptor modulator discovery and preclinical evaluation
    Jeremy O. Jones · 2009 · Expert Opinion on Drug Discovery
15. Capillarisin blocks prostate‐specific antigen expression on activation of androgen receptor in prostate carcinoma cells
    Ke-Hung Tsui, Ying-Ling Chang, Tsui-hsia Feng, Chen-Pang Hou, Yu-Hsiang Lin, Pei-Shan Yang, Bing-Wei Lee, H. Juang · 2018 · The Prostate
16. Reduced levels of stromal sex hormone-binding globulin and androgen receptor dysfunction in the sperm storage region of the rat epididymis
    Fabiane de Santi, Flávia Luciana Beltrame, Barry T. Hinton, Paulo Sérgio Cerri, Estela Sasso‐Cerri · 2018 · Reproduction
17. New Insights into the Androgen-Targeted Therapies and Epigenetic Therapies in Prostate Cancer
    Abhijit M. Godbole, Vincent C.O. Njar · 2011 · Prostate Cancer
18. Glutamic Acid 709 Substitutions Highlight the Importance of the Interaction between Androgen Receptor Helices H3 and H12 for Androgen and Antiandrogen Actions
    Virginie Georget, William Bourguet, Serge Lumbroso, Salouah Makni, Charles Sultan, Jean‐Claude Nicolas · 2005 · Molecular Endocrinology
19. The Emerging Role of TPR-Domain Immunophilins in the Mechanism of Action of Steroid Receptors
    Gisela I. Mazaira, Mariana Lagadari, Alejandra G. Erlejman, Mario D. Galigniana · 2014 · Nuclear Receptor Research
20. Heat shock protein 90 is associated with hyperplasia and neoplastic transformation of canine prostatic epithelial cells.
    Chiara Palmieri, M. Mancini, C. Benazzi, L. Della Salda · 2014 · Journal of Comparative Pathology
21. Antischistosomal versus Antiandrogenic Properties of Aryl Hydantoin Ro 13-3978
    Chunkai Wang, Qingjie Zhao, Jaeki Min, Sakthivel Muniyan, Mireille Vargas, Xiaofang Wang, Yuxiang Dong, Rodney Kiplin Guy, Ming‐Fong Lin, Jennifer Keiser et al. · 2014 · American Journal of Tropical Medicine and Hygiene
22. Molecular genetics of prostate cancer: clinical translational opportunities.
    Andrea M. Vecchione, Fedra Gottardo, Leonard G. Gomella, Bernadette Wildemore, Matteo Fassan, Emma Bragantini, Francesco Cosimo Pagano, Raffaele Baffa · 2007 · PubMed
23. Expression, purification and primary crystallographic study of human androgen receptor in complex with DNA and coactivator motifs
    X. Edward Zhou, Kelly M. Suino-Powell, Phumzile L. Ludidi, Donald Patrick McDonnell, H. Eric Xu · 2009 · Protein Expression and Purification
24. NAD(P)H‐quinone oxidoreductase 1 silencing aggravates hormone‐induced prostatic hyperplasia in mice
    Hyosun Kim, Yong-Kyung Kim, So-Jin Park, S. Ryu, Ju-Young Jung · 2018 · Andrologia
25. Mechanism underlying the retarded nuclear translocation of androgen receptor splice variants
    Ye Liu, Yinyu Wang, Fangfang Wang, Jiexue Pan, Jing-Jing Xu, Jingyi Li, Chengliang Zhou, Guolian Ding, Yanting Wu, Xinmei Liu et al. · 2018 · Science China Life Sciences
26. Improving Strategies in the Development of Protein‐Downregulation‐Based Antiandrogens
    Rongyu Zhang, Chen‐Chao Huang, Xiaohui Xiao, Jinming Zhou · 2021 · ChemMedChem
27. Bicalutamide causes heart failure in an elderly patient with prostate cancer
    Kyrillos Guirguis · 2015 · Expert Opinion on Drug Safety
28. Cheminformatics Driven Development of Novel Therapies for Drug Resistant Prostate Cancer
    Fuqiang Ban, Kush Dalal, Eric Leblanc, Hélène Morin, Paul S. Rennie, Artem R Cherkasov · 2018 · Molecular Informatics
29. Development of drugs against hormone‐refractory prostate cancer
    Yukio Kageyama · 2008 · Drug Development Research
30. MDM2 regulates the stability of AR, AR-V7, and TM4SF3 proteins in prostate cancer
    Prabesh Khatiwada, Ujjwal Rimal, Zhengyang Han, Lirim Shemshedini · 2024 · Endocrine Oncology
31. A mitochondrial outer membrane protein TOMM20 maintains protein stability of androgen receptor and regulates AR transcriptional activity in prostate cancer cells
    Linglong Yin, Yi Dai, Yue Wang, Shiwen Liu, Yubing Ye, Yongming Fu, Yuchong Peng, Ruizheng Tan, Fang Li, Haoran Suo et al. · 2025 · Oncogene
32. Evaluation of prostate-specific antigen as a novel biomarker of Hsp90 inhibition.
    K. Oikonomopoulou, A. Soosaipillai, E. Diamandis · 2009 · Clinical Biochemistry
33. Comparative proteomic analysis of male and female androgenetic alopecia: elucidating gender-specific molecular patterns
    Sasin Charoensuksira, Jitlada Meephansan, Raksanawan Vanichvongvan, Poorichaya Somparn, Pattarin Tangtanatakul, Jongkonnee Wongpiyabovorn, Poonkiat Suchonwanit · 2024 · Archives of Dermatological Research
34. An androgen-independent mechanism underlying the androgenic effects of 3-methylcholanthrene, a potent aryl hydrocarbon receptor agonist.
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36. Cell Biology of Prostate Cancer and Molecular Targets
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37. Decoding the Epigenetics and Chromatin Loop Dynamics of Androgen Receptor-Mediated Transcription
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38. Heat Shock Protein 90 and the Proteasome
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39. Androgen Receptor-Mediated Nuclear Transport of NRDP1 in Prostate Cancer Cells Is Associated with Worse Patient Outcomes
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41. Current progression of progesterone receptor and androgen receptor in endometrial cancer
    Lin Qi, Shuchang Liu, Shengli Wang, Chunyu Wang, Yue Zhao · 2026 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
42. Role of androgen receptor co-repressor SLIRP in cell cycle regulation
    De Silva, Dinuka · 2019 · Carolina Digital Repository (University of North Carolina at Chapel Hill)
43. HDAC6 Regulation of Androgen Signaling in Prostate Cancer
    Junkui Ai, Zhou Wang · 2013 · Springer eBooks
44. Cellular and Molecular Signatures of Androgen Ablation of Prostate Cancer
    Clifford G. Tepper, Hsing-Jien Kung · 2009 · Springer eBooks
45. Targeting Heat Shock Proteins in Multiple Myeloma
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46. 3C. 3-Ketosteroid receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database
    Derek W. Cain, John Anthony Cidlowski, Dean P. Edwards, Peter J. Fuller, Sandra L. Grimm, Sean Michael Hartig, Carol Ann Lange, Robert H. Oakley, Jennifer K. Richer, Carol A. Sartorius et al. · 2019 · IUPHAR/BPS Guide to Pharmacology CITE
47. THE ROLE OF LIGAND IN THE INTERACTION OF ANDROGEN RECEPTOR WITH DNA AND COACTIVATORS
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48. Decoding the Epigenetics and Chromatin Loop Dynamics of Androgen Receptor-Mediated Transcription
    Nathan A. Lack, Umut Berkay Altıntaş, Ji-Heu Seo, Claudia Giambartolomei, Doğancan Özturan, Brad J. Fortunato, Geoffrey M. Nelson, Seth Raphael Goldman, Karen Adelman, Faraz Hach et al. · 2024 · Research Square
49. Targeting Hsp90 in Cancer and Neurodegenerative Disease
    Len Neckers, Percy S. Ivy · 2009 · Springer eBooks
50. Key Roles of TGF-β and Smad3 in Prostate Cancer
    Kyung W. Song, David Danielpour · 2008 · Humana Press eBooks
51. Novel Small Molecule Antagonists of the Interaction of the Androgen Receptor and Transcriptional Co-regulators
    Clémentine Féau · 2008 · Defense Technical Information Center (DTIC)
52. The Hsp90-Based Protein Trafficking System and Linkage to Protein Quality Control
    Yoichi Osawa, William B. Pratt, Yoshihiro Morishima, Andrew P. Lieberman · 2012 · Heat shock proteins
53. Modulation of Androgen Receptor Transcriptional Activity
    Hao Yun Wong · 2009 · RePub (Erasmus University Rotterdam)
54. Characterizing Molecular Modifiers of Pathogenesis in Spinobulbar Muscular Atrophy.
    Carreon Chua, Jason E. Portnof · 2015
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    L.M. Verkleija, A.L.M. Venb, M. Wohlgemuthc, F.A. Kruytd · 2010 · Tijdschrift voor Gerontologie en Geriatrie
56. Heat Shock Protein 90 and the Proteasome
    Len Neckers · 2008 · Elsevier eBooks
57. Investigating the role of amino acid transporter LAT3/SLC43A1 in prostate cancer
    Kun Zhang · 2019 · The Sydney eScholarship Repository (The University of Sydney)
58. THE PHYSIOPATHOLOGICAL ROLES OF ANDROGENS IN MOTONEURONS
    Angelo Poletti · 2020 · Istituto Lombardo - Accademia di Scienze e Lettere - Incontri di Studio
59. Rôle du cholestérol et des récepteurs nucléaires LXRs dans le cancer de la prostate
    Aurélien Pommier · 2010
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61. Rol de los andrógenos sobre la capacidad termogénica y la generación de adipocitos beige del tejido adiposo blanco
    Alejandro Ezequiel Harnichar · 2022
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    Juan Alberto Serrano Olvera, Diego Osorio Pérez, Alejandro Noguez-Ramos, Raul Gerardo Ramirez Medina, Adriana Jiménez Cantero, Luis Fernando Manríquez-Cedillo de la Borbolla · 2022 · Anales Médicos de la Asociación Médica del Centro Médico ABC
63. Data from A Novel HSP90 Inhibitor Delays Castrate-Resistant Prostate Cancer without Altering Serum PSA Levels and Inhibits Osteoclastogenesis
    François Lamoureux, Christian Thomas, Min-Jean Yin, Hidetoshi Kuruma, Ladan Fazli, Martin Edwin Gleave, Amina Zoubeidi · 2023
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65. Mechanisms of Sex Disparities in Cardiovascular Function and Remodeling
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66. Therapy-induced PSMA2 Sensitizes Prostate Cancer Cells to Residual Androgen and Promotes Neuroendocrine Lineage Transformation
    Nadia Patterson, Andrei Badoi, Gangadhara Prasadachari Vadla, M Hasani, J Moyer, C De la Nuez Ramirez, Chiswili Yves Chabu · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
67. Op onduidelijke wijze in een rolstoel beland
    L. M. Verkleij, A. L. M. van de Ven, M. Wohlgemuth, F. A. Kruyt · 2010 · Tijdschrift voor Gerontologie en Geriatrie
68. Dérégulation de la signalisation non génomique du récepteur aux androgènes dans un modèle SBMA in vitro
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69. BindingDB Entry 50015426: Studies of targeting and intracellular trafficking of an anti-androgen doxorubicin-formaldehyde conjugate in PC-3 prostate cancer cells bearing androgen receptor-GFP chimera.
    BindingDB · 2009 · UC San Diego
70. BindingDB Entry 50033871: Inhibitors of androgen receptor activation function-2 (AF2) site identified through virtual screening.
    BindingDB · 2012 · UC San Diego