Glycogen Synthase Kinase 3β Phosphorylates Alzheimer's Disease-Specific Ser396 of Microtubule-Associated Protein Tau by a Sequential Mechanism
Li, Tong, Paudel, Hemant K.·2006·Biochemistry
Cited by (141)
Items 101–141 of 141
- Cystatin C promotes tau protein phosphorylation and causes microtubule instability by inhibiting intracellular turnover of GSK3β in neuronsJinhai Duan, Kristen A. Marcellus, Xike Qin, Yunling Wang, Hemant K. Paudel · 2018 · Molecular and Cellular Neuroscience
- Technical considerations in detection of HERV-K in amyotrophic lateral sclerosis: selection of controls and the perils of qPCRMarta Garcia Montojo, Wenxue Li, Avindra Nath · 2019 · Acta Neuropathologica Communications
- Specific phosphorylation of microtubule-associated protein 2c by extracellular signal–regulated kinase reduces interactions at its Pro-rich regionsJitka Plucarová, Séverine Jansen, Subhash Narasimhan, Alice Laníková, Marc Lewitzky, Stephan M. Feller, Lukáš Žı́dek · 2022 · Journal of Biological Chemistry
- DpdtpA, A Multi-metal Ion Chelator, Attenuates Tau Phosphorylation and Microglial Inflammatory Response via Regulating the PI3K/AKT/GSK-3β Signal PathwaysLu Wang, Yingjuan Wei, Zhenzhou Sun, Lin‐Hua Jiang, Yaling Yin, Panpan Zheng, Yun Fu, Hongwei Wang, Changzheng Li, Jian‐Zhi Wang · 2023 · Neuroscience
- FTDP-17 missense mutations site-specifically inhibit as well as promote dephosphorylation of microtubule-associated protein tau by protein phosphatases of HEK-293 cell extractDong Cho Han, Hemant K. Paudel · 2008 · Neurochemistry International
- APOE3 Christchurch modulates tau phosphorylation and β-catenin/Wnt/Cadherin signaling in induced pluripotent stem cell-derived cerebral organoids from Alzheimer’s casesRandall C. Mazzarino, Paula Andrea Perez-Corredor, Timothy E. Vanderleest, Guido N. Vacano, Justin S. Sanchez, Nelson David Villalba‐Moreno, S Krausemann, MA Mendivil-Perez, David Fernando Aguillon, Marlene Jiménez-Del-Río et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- CRISPRi-based screens in iAssembloids to elucidate neuron-glia interactionsEmmy Li, Camila Benitez, Steven C. Boggess, Mark Koontz, Indigo V.L. Rose, Delsy Martinez, Nina M. Dräger, Olivia M. Teter, Avi J. Samelson, Na’im Pierce et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- Long-term depression-related tau phosphorylation is enhanced by methylene blue in healthy rat hippocampusCem Süer, N. Yıldız Demircan, Özlem Barutçu, Burak Tan, Nurcan Dursun · 2021 · Pharmacological Reports
- High-Fat Diet-Induced Diabetic Conditions Exacerbate Cognitive Impairment in a Mouse Model of Alzheimer's Disease Via a Specific Tau Phosphorylation PatternYuki Ito, Shuko Takeda, Tsuneo Nakajima, A. Oyama, Haruo Takeshita, Kazumasa Miki, Yoichi Takami, Yasushi Takeya, Munehisa Shimamura, Hiromi Rakugi et al. · 2023 · The Journal of Prevention of Alzheimer s Disease
- Molecular Pathways in Alzheimer’s Disease and Cognitive FunctionXu Chen, Meredith C. Reichert, Li Gan · 2016 · Elsevier eBooks
- Tau hyperphosphorylation and axonal damage induced by N,N‐diethyldithiocarbamate (DEDTC) treatment along late postnatal development is followed by a rescue during adulthoodJuana Utrera, Fèlix Junyent, Luísa de Lemos, Mercè Pallàs, Antoni Camins, Rafael Romero, Carme Auladell · 2009 · Journal of Neuroscience Research
- The Effect of the Tau Protein on D. melanogaster Lifespan Depends on GSK3 Expression and SexEkaterina R. Veselkina, Mikhail V. Trostnikov, Natalia V. Roshina, ELENA G. PASYUKOVA · 2023 · International Journal of Molecular Sciences
- Mangiferin Alleviates Formaldehyde‐Induced Tau Hyperphosphorylation and Cognitive Impairment in Mice via the PI3K/AKT/GSK3β Pathway: Insights From Network Pharmacology and Experimental ValidationNa Wang, Ziteng Sun, Fan Chen, Xinyan Tian, Juan Li, Xiaping He · 2026 · The FASEB Journal
- Unique Pathology in the Locus Coeruleus of Individuals with Down SyndromeHannah Saternos, Eric Daniel Hamlett, Samuel J. Guzman, Elizabeth Head, Ann‐Charlotte Granholm, Aurélie Ledreux · 2024 · Journal of Alzheimer s Disease
- Drug Discovery from Medicinal Plants against Alzheimer's DiseaseMona M. Marzouk, Mai Mohammed Farid, Nesrine Mahmoud Hegazi, Shahira M. Ezzat · 2023 · Wiley eBooks
- Accessing intractable, phosphorylated intrinsically disordered proteins via a protease‐cleavable inclusion body tagCat Hoang Vesely, Stanislau Stanisheuski, Edward Lien, Patrick N. Reardon, Peter J. Chung, Ryan A. Mehl, Richard B. Cooley · 2026 · Protein Science
- Generation of induced pluripotent stem cells with high efficiency from human embryonic renal cortical cells.Ling Yao, Ruifang Chen, Pu Wang, Qi Zhang, Hailiang Tang, Huaping Sun · 2016 · PubMed Central
- Tau Phosphorylation and Amyloid-β Deposition in the Presence of FormaldehydeJing Lü, Rongqiao He · 2017 · Springer eBooks
- Therapeutic targeting of glycogen synthase kinase-3: Strategy to address neurodegenerative diseasesSaba Noor, Ali Raza, Md. Imtaiyaz Hassan · 2022 · Elsevier eBooks
- Distinct Hippocampal Expression Profiles of lncRNAs in Obese Type 2 Diabetes Mice Exhibiting Cognitive ImpairmentQianqian Xu, Lihui Wang, Qiong Song, Shuai Chen, Kechen Du, Xiahong Teng, Chunlin Zou · 2024 · NeuroMolecular Medicine
- SARS-CoV-2 infection leads to Tau pathological signature in neuronsCristina Di Primio, Paola Quaranta, Marianna Mignanelli, Giacomo Siano, Matteo Bimbati, Carmen Rita Piazza, Pietro Giorgio Spezia, Paola Perrera, Fulvio Basolo, Anello Marcello Poma et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- Non‐amyloid Approaches To Alzheimer's DiseaseLone Veng, Mary J. Savage, James C. Barrow, Celina Zerbinatti · 2010 · Wiley eBooks
- Molecular Mechanisms of Tau Protein Aggregation InhibitionElias Akoury · 2013
- Regulation by Glycogen Synthase Kinase-3 Beta of CBP transcriptional coactivator involved in insulin-dependent glucagon gene transcriptionAndrei Matsiulka · 2007
- Using TUDCA to treat Alzheimer's disease after pathology onset in APP/PS1 micePedro Dionísio · 2014 · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)
- Using TUDCA to treat Alzheimer's disease after pathology onset in APP/PS1 miceFaculdade De Farmácia · 2014
- Relationship of Adult Neurogenesis with Tau Phosphorylation and GSK-3b Activity in Subventricular ZoneXiao-Ping HongCai-Xia, Peng-Wei Wei · 2011
- Methylmercury and Cellular Signal Transduction SystemsMasatake Fujimura, Fusako Usuki · 2022 · Springer eBooks
- Unprecedented prospects as forthcoming drug targets: New boulevard in the cure and treatment of neurodegenerative disordersDipanjan Karati, Swarupananda Mukherjee, Nandita Batabyal · 2024 · Elsevier eBooks
- Amyloid β Deposition, Tau Phosphorylation, ApoE4 Dysfunction, and FormaldehydeJing Lü, Rongqiao He · 2025 · Springer eBooks
- APOE4-APP interactions exert early influences on cerebrovascular structure and function: implications for Alzheimer’s diseaseLanboling Guo, Jessica Ruth Gaunt, Calvin Chee Hoe Cheah, Albert I. Chen, Stephanie Claudine, Gavin Stewart Dawe, Eyleen Lay Keow Goh, Sok-Hong Kho, Pawan Kumar, Grace G. Y. Lim et al. · 2025 · Frontiers in Neuroscience
- Amyloid-β and phosphorylated-tau accumulation in retrosplenial cortex of young Alzheimer's disease model: Impact on network activityCarlos A García-Carlos, Anahí Salas-Gallardo, Perla González-Pereyra, Gustavo Basurto-Islas, George Perry, S. Mondragón-Rodríguez · 2026 · Journal of Alzheimer's Disease
- Tau nucléaire : un acteur clé dans le stress neuronalAudrey Sultan · 2010 · theses.fr (ABES)
- Prévention du phénomène de nucléation et de la propagation des tauopathies par immunothérapie passive utilisant un anticorps ciblant une région centrale de la protéine tauMarie Albert · 2018 · theses.fr (ABES)
- Neurotoxicité précoce et mécanismes de neuroprotection dans des modèles poisson‐zèbre de tauopathiesClément Barbereau · 2020 · theses.fr (ABES)
- Tau pSer396 and pSer404 Define Distinct Epitope Regions Linked to Different Antibody FunctionsRuimin Pan, Erin E. Congdon, Jessica E. Chukwu, Christina C. Luo, Einar M. Sigurdsson, Xiang‐Peng Kong · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Phosphoproteomics identifies Rho-kinase-associated phospho-signaling and autophagy-associated alterations in the medial prefrontal cortex of a schizophrenia-related mouse modelWenjun Zhu, Rinako Tanaka, Tetsuo Matsuzaki, Tsuyoshi Nakai, Taku Nagai, Toshitaka Nabeshima, Kozo Kaibuchi, Norio Ozaki, Hiroaki Ikesue, Hiroyuki Mizoguchi et al. · 2026 · Pharmacological Research
- The protein kinase B pathway as therapeutic target in neurodegenerative diseases: mechanisms and implicationsRosina Sánchez-Thomas, Sandra Monserrat Bautista-Perez, Ricardo A. Santana-Martínez, Carlos Alfredo Silva‐Islas, Alejandra Figueroa, Diana Barrera‐Oviedo, Perla D. Maldonado · 2026 · Elsevier eBooks
- The Tau-mitochondria connection and its impact on cellular energy metabolism in Alzheimer’s diseaseAbhay Kumar Singh, Supraja M.R., Amal P.S., Senthilkumar Krishnamoorthi, Ashok Iyaswamy, Siva Sundara Kumar Durairajan · 2026 · International review of neurobiology
- BindingDB Entry 50033570: Switching reversibility to irreversibility in glycogen synthase kinase 3 inhibitors: clues for specific design of new compounds.BindingDB · 2012 · UC San Diego
- APH-1A and CDK5 Expression Correlates with Tau Hyperphosphorylation and Its Attenuation by Brahmi and Donep-M in STZ induced Alzheimer’s Disease ModelUmesh Prasad Sah Hathi, Abhishek Kumar, Arora Jyotsna, Suneel Kateriya · 2026 · Research Square