The DOI matches its Crossref record; 134 of the 134 references it cites were found in a registry or an index.
tRNA Stabilization by Modified Nucleotides
Abstract
Post-transcriptional ribonucleotide modification is a phenomenon best studied in tRNA, where it occurs most frequently and in great chemical diversity. This paper reviews the intrinsic network of modifications in the structural core of the tRNA, which governs structural flexibility and rigidity to fine-tune the molecule to peak performance and to regulate its steady-state level. Structural effects of RNA modifications range from nanometer-scale rearrangements to subtle restrictions of conformational space on the angstrom scale. Structural stabilization resulting from nucleotide modification results in increased thermal stability and translates into protection against unspecific degradation by bases and nucleases. Several mechanisms of specific degradation of hypomodified tRNA, which were only recently discovered, provide a link between structural and metabolic stability.
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Cites
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Characterization of the piRNA Complex from Rat Testes
Iseni, F., Barge, A., Baudin, F., Blondel, D., Ruigrok, R. W. H., Schoehn, G., & Mavrakis, M. (2006) · Cited by 714
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Cited by
Prebiotic Systems Chemistry: New Perspectives for the Origins of Life
Ruiz-Mirazo, K., Briones, C., & de la Escosura, A. (2014) · Chemical Reviews · doi:10.1021/cr2004844 · Cited by 930
Human Mitochondrial tRNAs: Biogenesis, Function, Structural Aspects, and Diseases
Suzuki, T., Nagao, A., & Suzuki, T. (2011) · Annual Review of Genetics · doi:10.1146/annurev-genet-110410-132531 · Cited by 559
Bohnsack, K. E., Höbartner, C., & Bohnsack, M. T. (2019) · Genes · doi:10.3390/genes10020102 · Cited by 517
A Quantitative Systems Approach Reveals Dynamic Control of tRNA Modifications during Cellular Stress
Chan, C. T. Y., Dyavaiah, M., DeMott, M. S., Taghizadeh, K., Dedon, P. C., & Begley, T. J. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1001247 · Cited by 465
Epitranscriptome sequencing technologies: decoding RNA modifications
Li, X., Xiong, X., & Yi, C. (2017) · Nature Methods · doi:10.1038/nmeth.4110 · Cited by 447
Metadata
- Authors
- Motorin, Y., & Helm, M.
- Venue
- Biochemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2010-05-26
- Volume
- 49
- Issue
- 24
- Pages
- 4934-4944
- ISSN
- 0006-2960 (ISSN-L)
- 1520-4995
- OpenAlex
- W2037577397
- Cited by
- 472
- References
- 134
- FWCI
- 9.22
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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