Control of Glucocorticoid and Progesterone Receptor Subcellular Localization by the Ligand-Binding Domain Is Mediated by Distinct Interactions with Tetratricopeptide Repeat Proteins

Banerjee, Ananya; Periyasamy, Sumudra; Wolf, Irene M.; Hinds, Terry D.; Yong, Weidong; Shou, Weinian; Sanchez, Edwin R.

doi:10.1021/bi8011862

Control of Glucocorticoid and Progesterone Receptor Subcellular Localization by the Ligand-Binding Domain Is Mediated by Distinct Interactions with Tetratricopeptide Repeat Proteins

The TPR proteins FKBP52, FKBP51, Cyp40 and PP5 are found in steroid receptor (SR) complexes but their receptor-specific preferences and roles remain unresolved. We have undertaken a systematic approach to this problem by examining the contribution of all four TPRs to the localization properties o…