CoChat
Sign Up
Cited by 76

The DOI matches its Crossref record.

Spectral Tuning in the Human Blue Cone Pigment

Fasick, Jeffry I., Lee, Ning, Oprian, Daniel D.·1999·Biochemistry
DOI 10.1021/bi991600h
Open this paper in CoChat — free account

Abstract

The first determination of the absolute absorption maximum of the human blue cone visual pigment is presented. After expression in COS cells, reconstitution with 11-cis-retinal, and purification, the blue pigment exhibits an absolute absorption maximum of 414 nm. The pigment reacts rapidly with hydroxylamine in the dark and is capable of activating bovine rod transducin in a light-dependent manner. Products of mutations of proposed spectral tuning residues in the blue pigment do not behave as predicted when using rhodopsin mutants as a model. Mutations of amino acids in the ring portion of the chromophore binding pocket of rhodopsin serve well as a predictive model for mutations in the blue pigment, but mutations near the Schiff base do not.

Overview

Integrity signals

Registry

Crossref · 10.1021/bi991600h

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 23

  1. Brown P. K., 1964, Science, 144, 52, 10.1126/science.144.3614.45 · DOI
  2. Dartnall H. J., 1983, Proc. R
  3. Oprian D. D., 1991, Biochemistry 30, 11367−11372
  4. Merbs S. L., 1992, Nature 356, 433−435
  5. Yokoyama S., 1998, FEBS Lett., 423, 10.1016/S0014-5793(98)00086-6 · DOI
  6. Wilkie S. E., 1998, Biochem. J., 330, 10.1042/bj3300541 · DOI
  7. Ferretti L., 1986, Proc. Natl. Acad. Sci. U.S.A. 83, 599−603
  8. Oprian D. D., 1987, Proc. Natl. Acad. Sci. U.S.A. 84, 8874−8878
  9. Zhukovsky E. A., 1991, Science 251, 558−560
  10. Hong K., 1973, Biochemistry 12, 4517−4523
  11. Okano T., 1989, Biochemistry 28, 8848−8856
  12. Lin S. W., 1998, J. Biol. Chem., 273
  13. Nakayama T. A., 1990, J. Biol. Chem., 265
  14. Zhang H., 1994, J. Am. Chem. Soc., 116
  15. Rao V. R., 1994, Nature 367, 639−642
  16. Dryja T. P., 1993, Nat. Genet. 4, 280−283
  17. Sun H., 1997, Proc. Natl. Acad. Sci. U.S.A. 94, 8860−8865
  18. Fasick J. I., 1998, Biochemistry 37, 433−438
  19. Zhukovsky E. A., 1989, Science 246, 928−930
  20. Sakmar T. P., 1989, Proc. Natl. Acad. Sci. U.S.A. 86, 8309−8313
  21. Nathans J., 1990, Biochemistry 29, 9746−9752
  22. Wessling-Resnick M., 1987, J. Biol. Chem., 262
  23. Abbreviations DM, n-dodecyl β-d-maltoside

Cited by

Sorted by citations

Metadata

Authors
Fasick, J. I., Lee, N., & Oprian, D. D.
Affiliations
Department of Biochemistry and Volen Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454
Venue
Biochemistry
Publisher
American Chemical Society (ACS)
Published
1999-08-19
Volume
38
Issue
36
Pages
11593-11596
ISSN
  • 0006-2960
  • 1520-4995
DOI
10.1021/bi991600h
Cited by
76
References
0
Language
en

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review