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Rheology of Sodium Hyaluronate under Physiological Conditions
Abstract
Sodium hyaluronate NaHA in phosphate-buffered saline behaves as a typical polyelectrolyte in the high-salt limit, as Newtonian viscosities are observed over a wide range of shear rates. There is no evidence of intermolecule hydrogen bonding causing gel formation in NaHA solutions without protein present. The concentration dependences of viscosity, relaxation time, and terminal modulus are consistent with observations on flexible, neutral polymers in good solvents, which are known to be in the same universality class as flexible polyelectrolytes in the presence of excess salt.
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Cited by
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McKee, M. G., Wilkes, G. L., Colby, R. H., & Long, T. E. (2004) · Macromolecules · doi:10.1021/ma035689h · Cited by 699
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Interstitial Pressure in Pancreatic Ductal Adenocarcinoma Is Dominated by a Gel-Fluid Phase
DuFort, C. C., DelGiorno, K. E., Carlson, M. A., Osgood, R. J., Zhao, C., Huang, Z., Thompson, C. B., Connor, R. J., Thanos, C. D., Scott Brockenbrough, J., et al. (2016) · Biophysical Journal · doi:10.1016/j.bpj.2016.03.040 · Cited by 171
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Metadata
- Authors
- Krause, W. E., Bellomo, E. G., & Colby, R. H.
- Venue
- Biomacromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 2001-01-16
- Volume
- 2
- Issue
- 1
- Pages
- 65-69
- ISSN
- 1525-7797 (ISSN-L)
- 1526-4602
- OpenAlex
- W2089232392
- Cited by
- 248
- References
- 0
- FWCI
- 6.46
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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