The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Rational Design of Cytophilic and Cytophobic Polyelectrolyte Multilayer Thin Films
Abstract
Nanostructured polyelectrolyte multilayer thin films electrostatically assembled alternately from such polymers as poly(allylamine hydrochloride) (PAH) and poly(acrylic acid) (PAA) were investigated for their in vitro cell interactions. Not surprisingly, NR6WT cells, a highly adhesive murine fibroblast cell line, attached to many different multilayer combinations tested. However, PAH/PAA multilayers constructed at pH deposition conditions of 2.0/2.0 were completely bioinert. Analogous cell interactions were observed with PAH/poly(methacrylic acid) (PAH/PMA), PAH/sulfonated poly(styrene) (PAH/SPS), and poly(diallyldimethylammonium chloride)/SPS (PDAC/SPS) systems, thereby suggesting a general trend in the fibroblasts' response to multilayers. Specifically, highly ionically stitched films attracted cells, whereas weakly ionically cross-linked multilayers, which swell substantially in physiological conditions to present richly hydrated surfaces, resisted fibroblast attachment. Thus, by manipulating the multilayer pH or ionic strength assembly conditions or both, which in turn dictate the molecular architecture of the thin films, one may powerfully direct a single multilayer combination to be either cell adhesive or cell resistant.
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Citations
Cites
Biological Responses to Materials
Anderson, J. M. (2001) · Annual Review of Materials Research · doi:10.1146/annurev.matsci.31.1.81 · Cited by 1,465
Luk, Y.-Y., Kato, M., & Mrksich, M. (2000) · Langmuir · doi:10.1021/la0004653 · Cited by 414
Cited by
Engineering biomaterials to integrate and heal: The biocompatibility paradigm shifts
Bryers, J. D., Giachelli, C. M., & Ratner, B. D. (2012) · Biotechnology and Bioengineering · doi:10.1002/bit.24559 · Cited by 271
Development of Cationic Polymer Coatings to Regulate Foreign‐Body Responses
Ma, M., Liu, W. F., Hill, P. S., Bratlie, K. M., Siegwart, D. J., Chin, J., Park, M., Guerreiro, J., & Anderson, D. G. (2011) · Advanced Materials · doi:10.1002/adma.201100513 · Cited by 59
Metadata
- Authors
- Mendelsohn, J. D., Yang, S. Y., Hiller, J., Hochbaum, A. I., & Rubner, M. F.
- Venue
- Biomacromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 2002-11-06
- Volume
- 4
- Issue
- 1
- Pages
- 96-106
- ISSN
- 1525-7797 (ISSN-L)
- 1526-4602
- OpenAlex
- W2056145482
- Cited by
- 461
- References
- 2
- FWCI
- 22.97
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mendelsohn, J. D., Yang, S. Y., Hiller, J., Hochbaum, A. I., & Rubner, M. F. (2003). Rational Design of Cytophilic and Cytophobic Polyelectrolyte Multilayer Thin Films. Biomacromolecules. https://doi.org/10.1021/bm0256101
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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