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Living Polypeptides
Abstract
Block copolypeptides, which combine the self-assembly of block copolymers and the highly ordered 3D structures of proteins, are potential candidates for novel supramolecular structures and biotech applications, such as biosensors, tissue engineering, and selective drug delivery. The synthesis of model block copolypeptides through living nucleophilic/basic polymerization of alpha-amino acid N-carboxyanhydrides (NCAs) has been a challenge for more than fifty years, most probably due to traces of impurities in the system. This problem has been overcome, using high vacuum techniques in order to create and maintain the conditions necessary for the living polymerization of NCAs with primary amines. This method is a general one and opens avenues leading to novel, well-defined polypeptides with various architectures.
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Citations
Cited by
Polypeptides and 100 Years of Chemistry of α‐Amino Acid N‐Carboxyanhydrides
Kricheldorf, H. R. (2006) · Angewandte Chemie International Edition · doi:10.1002/anie.200600693 · Cited by 628
Hadjichristidis, N., Iatrou, H., Pitsikalis, M., & Sakellariou, G. (2009) · Chemical Reviews · doi:10.1021/cr900049t · Cited by 560
Self-citationSynthetic polypeptides for biomedical applications
Deming, T. J. (2007) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2007.05.010 · Cited by 552
Gan, B. H., Gaynord, J., Rowe, S. M., Deingruber, T., & Spring, D. R. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00729c · Cited by 511
Hydrogels as smart biomaterials
Kopeček, J., & Yang, J. (2007) · Polymer International · doi:10.1002/pi.2253 · Cited by 425
Metadata
- Authors
- Aliferis, T., Iatrou, H., & Hadjichristidis, N.
- Venue
- Biomacromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 2004-07-10
- Volume
- 5
- Issue
- 5
- Pages
- 1653-1656
- ISSN
- 1525-7797 (ISSN-L)
- 1526-4602
- OpenAlex
- W4238167105
- Cited by
- 327
- References
- 0
- FWCI
- 8.05
- Type
- journal article
- Language
- en
- Open access
- closed
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