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Facile, Controlled, Room-Temperature RAFT Polymerization of N-Isopropylacrylamide
Abstract
Poly(N-isopropyl acrylamide) is a thermoresponsive polymer that has been widely investigated for drug delivery. Herein, we report conditions facilitating the controlled, room-temperature RAFT polymerization of N-isopropylacrylamide (NIPAM). The key to success is the appropriate choice of both a suitable RAFT chain transfer agent (CTA) and initiating species. We show that the use of 2-dodecylsulfanylthiocarbonylsulfanyl-2-methyl propionic acid, a trithiocarbonate RAFT CTA, in conjunction with the room-temperature azo initiator 2,2'-azobis(4-methoxy-2,4-dimethylvaleronitrile), in DMF, at 25 degrees C, yields conditions leading to NIPAM homopolymerizations which bear all of the characteristics of a controlled/"living" polymerization. We also demonstrate facile size exclusion chromatographic analysis of PNIPAM samples in DMF at 60 degrees C, directly on aliquots withdrawn during the polymerizations, which avoids the problems previously reported in the literature.
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Cited by
Xia, Y., Yin, X., Burke, N. A. D., & Stöver, H. D. H. (2005) · Macromolecules · doi:10.1021/ma050261z · Cited by 503
Thermoreversible Hyaluronic Acid‐PNIPAAm Hydrogel Systems for 3D Stem Cell Culture
Ekerdt, B. L., Fuentes, C. M., Lei, Y., Adil, M. M., Ramasubramanian, A., Segalman, R. A., & Schaffer, D. V. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201800225 · Cited by 117
Mahmoud, W. E., & Al-Bluwi, S. A. (2020) · Sensors and Actuators A: Physical · doi:10.1016/j.sna.2020.112101 · Cited by 58
Metadata
- Authors
- Convertine, A. J., Ayres, N., Scales, C. W., Lowe, A. B., & McCormick, C. L.
- Venue
- Biomacromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 2004-06-24
- Volume
- 5
- Issue
- 4
- Pages
- 1177-1180
- ISSN
- 1525-7797 (ISSN-L)
- 1526-4602
- OpenAlex
- W1967549039
- Cited by
- 237
- References
- 0
- FWCI
- 16.10
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Facile, Controlled, Room-Temperature RAFT Polymerization of N-Isopropylacrylamide. https://app.cochat.ai/papers/10.1021/bm049825h
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- Convertine, A. J., Ayres, N., Scales, C. W., Lowe, A. B., & McCormick, C. L. (2004). Facile, Controlled, Room-Temperature RAFT Polymerization of N-Isopropylacrylamide. Biomacromolecules. https://doi.org/10.1021/bm049825h
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
