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Cited by 329

The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.

Physical Gelation of Chitosan in the Presence of β-Glycerophosphate: The Effect of Temperature

Cho, Jaepyoung, Heuzey, Marie-Claude, Bégin, André, Carreau, Pierre J.·2005·Biomacromolecules
DOI 10.1021/bm050313s
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Abstract

When adding beta-glycerophosphate (beta-GP), a weak base, to chitosan aqueous solutions, the polymer remains in solution at neutral pH and room temperature, while homogeneous gelation of this system can be triggered upon heating. It is therefore one of the rare true physical chitosan hydrogels. In this study, physicochemical and rheological properties of chitosan solutions in the presence of acetic acid and beta-GP were investigated as a function of temperature in order to gain a better understanding of the gelation mechanisms. The gel structure formed at high temperature was only partially thermoreversible upon cooling to 5 degrees C because of the existence of remaining associations, confirmed by the spontaneous recovery of the gel after breakup at low temperature. Increasing temperature had no effect on the pH values of this system, while conductivity (and calculated ionic strength) increased. Values from the pH measurements were used to estimate the degree of protonation of each species as a function of temperature. The decreasing ratio of -NH3+ in chitosan and -OPO(O-)2 in beta-GP suggested reduced chitosan solubility along with a diminution of ionic interactions such as ionic bridging with increasing temperature. On the other hand, the increased ionic strength as a function of temperature, in the presence of beta-GP, enhanced screening of electrostatic repulsion and increased hydrophobic effect, resulting in favorable conditions for gel formation. Therefore, our study suggests that hydrophobic interactions and reduced solubility are the main driving force for chitosan gelation at high temperature in the presence of beta-GP.

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Metadata

Authors
Cho, J., Heuzey, M.-C., Bégin, A., & Carreau, P. J.
Venue
Biomacromolecules
Publisher
American Chemical Society (ACS)
Published
2005-08-23
Volume
6
Issue
6
Pages
3267-3275
ISSN
  • 1525-7797 (ISSN-L)
  • 1526-4602
DOI
10.1021/bm050313s
OpenAlex
W2085648623
Cited by
329
References
24
FWCI
2.83
Type
journal article
Language
en
Open access
closed

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