The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Biocompatibility Testing of Branched and Linear Polyglycidol
Abstract
Polyglycidols are flexible hydrophilic polyethers that are potentially biocompatible polymers based on their similarities to the well-studied poly(ethyleneglycol). Polyglycidols can be prepared as branched or linear polymers by suitable synthetic methods. Biocompatibility testing of these polymers conducted in vitro as well as in vivo are reported here. The in vitro studies included hemocompatibility testing for effects on coagulation (PT and APTT), complement activation, red blood cell aggregation, and whole blood viscosity measurements. In vitro cytotoxicity experiments were also conducted. The results were compared with some of the common biocompatible polymers already in human use. Results from these studies show that polyglycidols are highly biocompatible. Hyperbranched polyglycidols were found to be well tolerated by mice even when injected in high doses.
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Poly(ethylene glycol) in Drug Delivery: Pros and Cons as Well as Potential Alternatives
Knop, K., Hoogenboom, R., Fischer, D., & Schubert, U. S. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.200902672 · Cited by 3,533
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In vitro biological evaluation of high molecular weight hyperbranched polyglycerols
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Self-citationThomas, A., Müller, S. S., & Frey, H. (2014) · Biomacromolecules · doi:10.1021/bm5002608 · Cited by 264
Protein–polymer conjugation — moving beyond PEGylation
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Metadata
- Authors
- Kainthan, R. K., Janzen, J., Levin, E., Devine, D. V., & Brooks, D. E.
- Venue
- Biomacromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 2006-02-22
- Volume
- 7
- Issue
- 3
- Pages
- 703-709
- ISSN
- 1525-7797 (ISSN-L)
- 1526-4602
- OpenAlex
- W2000947203
- Cited by
- 393
- References
- 16
- FWCI
- 18.37
- Type
- journal article
- Language
- en
- Open access
- closed
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