The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Redox-Responsive Polyphosphate Nanosized Assemblies: A Smart Drug Delivery Platform for Cancer Therapy
Abstract
Novel redox-responsive polyphosphate nanosized assemblies based on amphiphilic hyperbranched multiarm copolyphosphates (HPHSEP-star-PEP(x)) with backbone redox-responsive, good biocompatibility, and biodegradability simultaneously have been designed and prepared successfully. The hydrophobic core and hydrophilic multiarm of HPHSEP-star-PEP(x) are composed of hyperbranched and linear polyphosphates, respectively. Benefiting from the amphiphilicity, HPHSEP-star-PEP(x) can self-assemble into spherical micellar nanoparticles in aqueous media with tunable size from about 70 to 100 nm via adjusting the molecular weight of PEP multiarm. Moreover, HPHSEP-star-PEP(x) micellar structure can be destructed under reductive environment and result in a triggered drug release behavior. The glutathione-mediated intracellular drug delivery was investigated against a HeLa human cervical carcinoma cell line, and the results indicate that doxorubicin-loaded (DOX-loaded) HPHSEP-star-PEP(x) micelles show higher cellular proliferation inhibition against glutathione monoester pretreated HeLa cells than that of the nonpretreated ones. In contrast, the DOX-loaded micelles exhibit lower inhibition against buthionine sulfoximine pretreated HeLa cells. These results suggest that such redox-responsive polyphosphate micelles can rapidly deliver anticancer drugs into the nuclei of tumor cells enhancing the inhibition of cell proliferation and provide a favorable platform to construct excellent drug delivery systems for cancer therapy.
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Citations
Cites
Physical stimuli-responsive polymeric micelles for anti-cancer drug delivery
Rapoport, N. (2007) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2007.05.009 · Cited by 1,002
Recent progress in polyphosphoesters: From controlled synthesis to biomedical applications
Wang, Y., Yuan, Y., Du, J., Yang, X., & Wang, J. (2009) · Macromolecular Bioscience · doi:10.1002/mabi.200900253 · Cited by 203
Cited by
Zhang, Q., Re Ko, N., & Kwon Oh, J. (2012) · Chemical Communications · doi:10.1039/c2cc32408c · Cited by 395
Bioapplications of hyperbranched polymers
Wang, D., Zhao, T., Zhu, X., Yan, D., & Wang, W. (2015) · Chemical Society Reviews · doi:10.1039/c4cs00229f · Cited by 301
Self-citation
Metadata
- Authors
- Liu, J., Pang, Y., Huang, W., Zhu, Z., Zhu, X., Zhou, Y., & Yan, D.
- Venue
- Biomacromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 2011-05-16
- Volume
- 12
- Issue
- 6
- Pages
- 2407-2415
- ISSN
- 1525-7797 (ISSN-L)
- 1526-4602
- OpenAlex
- W2327242595
- Cited by
- 194
- References
- 2
- FWCI
- 23.18
- Type
- journal article
- Language
- en
- Open access
- closed
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