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Injectable Microgel-Hydrogel Composites for Prolonged Small-Molecule Drug Delivery
Abstract
The design and application of soft nanocomposite injectable hydrogels containing entrapped microgels for small-molecule drug delivery is demonstrated. Copolymer microgels based on N-isopropylacrylamide and acrylic acid were synthesized that exhibited both ionic and hydrophobic affinity for binding to bupivacaine, a cationic local anesthetic used as a model drug. Microgels were subsequently immobilized within an in situ-gelling hydrogel network cross-linked via hydrazide-aldehyde chemistry to generate hydrogel-microgel soft nanocomposites. Drug release could be sustained for up to 60 days from these nanocomposite hydrogels, significantly longer than that achievable using the constituent hydrogel or microgels alone (<1 week). Drug release kinetics could be readily tuned by varying the affinity of the microgel and hydrogel phases for drug-polymer interactions and the network density of the hydrogel phase.
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Cited by
Nanogels and Microgels: From Model Colloids to Applications, Recent Developments, and Future Trends
Karg, M., Pich, A., Hellweg, T., Hoare, T., Lyon, L. A., Crassous, J. J., Suzuki, D., Gumerov, R. A., Schneider, S., Potemkin, I. I., et al. (2019) · Langmuir · doi:10.1021/acs.langmuir.8b04304 · Cited by 658
Self-citationNovel Mussel‐Inspired Injectable Self‐Healing Hydrogel with Anti‐Biofouling Property
Li, L., Yan, B., Yang, J., Chen, L., & Zeng, H. (2015) · Advanced Materials · doi:10.1002/adma.201405166 · Cited by 553
Yang, X., & Cranston, E. D. (2014) · Chemistry of Materials · doi:10.1021/cm502873c · Cited by 473
Metadata
- Authors
- Sivakumaran, D., Maitland, D., & Hoare, T.
- Venue
- Biomacromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 2011-10-24
- Volume
- 12
- Issue
- 11
- Pages
- 4112-4120
- ISSN
- 1525-7797 (ISSN-L)
- 1526-4602
- OpenAlex
- W2322706961
- Cited by
- 214
- References
- 0
- FWCI
- 6.97
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sivakumaran, D., Maitland, D., & Hoare, T. (2011). Injectable Microgel-Hydrogel Composites for Prolonged Small-Molecule Drug Delivery. Biomacromolecules. https://doi.org/10.1021/bm201170h
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
