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Aerogel Microspheres from Natural Cellulose Nanofibrils and Their Application as Cell Culture Scaffold
Abstract
We demonstrated that ultralight pure natural aerogel microspheres can be fabricated using cellulose nanofibrials (CNF) directly. Experimentally, the CNF aqueous gel droplets, produced by spraying and atomizing through a steel nozzle, were collected into liquid nitrogen for instant freezing followed by freeze-drying. The aerogel microspheres are highly porous with bulk density as low as 0.0018 g cm(-3). The pore size of the cellulose aeogel microspheres ranges from nano- to macrometers. The unique ultralight and high porous structure ensured high moisture (~90 g g(-1)) and water uptake capacity (~100 g g(-1)) of the aerogel microspheres. Covalent cross-linking between the native nanofibrils and cross-linkers made the aerogel microspheres very stable even in a harsh environment. The present study also confirmed this kind of aerogel microspheres from native cellulose fibers can be used as cell culture scaffold.
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Citations
Cited by
Chen, Y., Zhang, L., Yang, Y., Pang, B., Xu, W., Duan, G., Jiang, S., & Zhang, K. (2021) · Advanced Materials · doi:10.1002/adma.202005569 · Cited by 721
Alginate: From Food Industry to Biomedical Applications and Management of Metabolic Disorders
Gheorghita Puscaselu, R., Lobiuc, A., Dimian, M., & Covasa, M. (2020) · Polymers · doi:10.3390/polym12102417 · Cited by 470
Nanocellulose as a novel nanostructured adsorbent for environmental remediation: a review
Mahfoudhi, N., & Boufi, S. (2017) · Cellulose · doi:10.1007/s10570-017-1194-0 · Cited by 420
Synthesis and biomedical applications of aerogels: Possibilities and challenges
Maleki, H., Durães, L., García-González, C. A., del Gaudio, P., Portugal, A., & Mahmoudi, M. (2016) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2016.05.011 · Cited by 386
Nanocellulose-based lightweight porous materials: A review
Sun, Y., Chu, Y., Wu, W., & Xiao, H. (2021) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2020.117489 · Cited by 266
Metadata
- Authors
- Cai, H., Sharma, S., Liu, W., Mu, W., Liu, W., Zhang, X., & Deng, Y.
- Venue
- Biomacromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 2014-06-09
- Volume
- 15
- Issue
- 7
- Pages
- 2540-2547
- ISSN
- 1525-7797 (ISSN-L)
- 1526-4602
- OpenAlex
- W2332080658
- Cited by
- 212
- References
- 0
- FWCI
- 6.41
- Type
- journal article
- Language
- en
- Open access
- closed
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- Cai, H., Sharma, S., Liu, W., Mu, W., Liu, W., Zhang, X., & Deng, Y. (2014). Aerogel Microspheres from Natural Cellulose Nanofibrils and Their Application as Cell Culture Scaffold. Biomacromolecules. https://doi.org/10.1021/bm5003976
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
