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Polyelectrolyte Multilayers for Tunable Release of Antibiotics
Abstract
Polyelectrolyte multilayers incorporating gentamicin were fabricated using layer-by-layer deposition. The multilayers could be precisely tuned with regard to dosage, and release rate under aqueous physiological conditions could be controlled. The films were demonstrated efficacious against Staphylococcus aureus and nontoxic toward murine osteoblasts MC3T3. The films were made in a layer-by-layer process with a heterostructural architecture that represents a general strategy for incorporating charged small molecular species into polyelectrolyte multilayers without the need for any physical or chemical premodification, expanding the range of active species that can be delivered from these films while maintaining the ease of layer-by-layer fabrication process.
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Citations
Cited by
Banerjee, I., Pangule, R. C., & Kane, R. S. (2011) · Advanced Materials · doi:10.1002/adma.201001215 · Cited by 2,749
Dual-function antibacterial surfaces for biomedical applications
Yu, Q., Wu, Z., & Chen, H. (2015) · Acta Biomaterialia · doi:10.1016/j.actbio.2015.01.018 · Cited by 411
Recent advances in materials for extended-release antibiotic delivery system
Gao, P., Nie, X., Zou, M., Shi, Y., & Cheng, G. (2011) · The Journal of Antibiotics · doi:10.1038/ja.2011.58 · Cited by 310
Macdonald, M. L., Samuel, R. E., Shah, N. J., Padera, R. F., Beben, Y. M., & Hammond, P. T. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2010.10.052 · Cited by 298
Self-citationSelf-Defensive Layer-by-Layer Films with Bacteria-Triggered Antibiotic Release
Zhuk, I., Jariwala, F., Attygalle, A. B., Wu, Y., Libera, M. R., & Sukhishvili, S. A. (2014) · ACS Nano · doi:10.1021/nn500674g · Cited by 275
Metadata
- Authors
- Chuang, H. F., Smith, R. C., & Hammond, P. T.
- Venue
- Biomacromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-05-14
- Volume
- 9
- Issue
- 6
- Pages
- 1660-1668
- ISSN
- 1525-7797 (ISSN-L)
- 1526-4602
- OpenAlex
- W2036981697
- Cited by
- 182
- References
- 0
- FWCI
- 6.30
- Type
- journal article
- Language
- en
- Open access
- closed
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- Chuang, H. F., Smith, R. C., & Hammond, P. T. (2008). Polyelectrolyte Multilayers for Tunable Release of Antibiotics. Biomacromolecules. https://doi.org/10.1021/bm800185h
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