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Dynamic Cell Seeding of Polymer Scaffolds for Cartilage Tissue Engineering
Abstract
Cell seeding of three‐dimensional polymer scaffolds is the first step of the cultivation of engineered tissues in bioreactors. Seeding requirements of large scaffolds to make implants for potential clinical use include: (a) high yield, to maximize the utilization of donor cells, (b) high kinetic rate, to minimize the time in suspension for anchorage‐dependent and shear‐sensitive cells, and (c) high and spatially uniform distribution of attached cells, for rapid and uniform tissue regeneration. Highly porous, fibrous polyglycolic acid scaffolds, 5–10 mm in diameter and 2–5 mm thick, were seeded with bovine articular chondrocytes in well‐mixed spinner flasks. Essentially, all cells attached throughout the scaffold volume within 1 day. Mixing promoted the formation of 20–32‐μm diameter cell aggregates that enhanced the kinetics of cell attachment without compromising the uniformity of cell distribution. The kinetics and possible mechanisms of cell seeding were related to the formation of cell aggregates by a simple mathematical model that can be used to optimize seeding conditions for cartilage tissue engineering.
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Cited by
3D biofabrication strategies for tissue engineering and regenerative medicine
Bajaj, P., Schweller, R. M., Khademhosseini, A., West, J. L., & Bashir, R. (2014) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-071813-105155 · Cited by 632
Polyglycolic Acid-Induced Inflammation: Role of Hydrolysis and Resulting Complement Activation
Ceonzo, K., Gaynor, A., Shaffer, L., Kojima, K., Vacanti, C. A., & Stahl, G. L. (2006) · Tissue Engineering · doi:10.1089/ten.2006.12.301 · Cited by 209
Development and analysis of multi-layer scaffolds for tissue engineering
Papenburg, B. J., Liu, J., Higuera, G. A., Barradas, A. M. C., de Boer, J., van Blitterswijk, C. A., Wessling, M., & Stamatialis, D. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.07.057 · Cited by 125
Metadata
- Authors
- Vunjak‐Novakovic, G., Obradovic, B., Martin, I., Bursac, P. M., Langer, R., & Freed, L. E.
- Venue
- Biotechnology Progress
- Publisher
- Wiley
- Published
- 1998-01
- Volume
- 14
- Issue
- 2
- Pages
- 193-202
- ISSN
- 1520-6033 (ISSN-L)
- 8756-7938
- OpenAlex
- W2081312806
- Cited by
- 551
- References
- 0
- FWCI
- 18.13
- Type
- journal article
- Language
- en
- Open access
- closed
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- Vunjak‐Novakovic, G., Obradovic, B., Martin, I., Bursac, P. M., Langer, R., & Freed, L. E. (1998). Dynamic Cell Seeding of Polymer Scaffolds for Cartilage Tissue Engineering. Biotechnology Progress. https://doi.org/10.1021/bp970120j
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