Stabilizing the Pro-Apoptotic BimBH3 Helix (BimSAHB) Does Not Necessarily Enhance Affinity or Biological Activity

Cited by (141)

Items 101–141 of 141

1. Dynamics of the BH3-Only Protein Binding Interface of Bcl-xL
   Xiaorong Liu, Alex Beugelsdijk, Jianhan Chen · 2015 · Biophysical Journal
2. BH3 helix-derived biophotonic nanoswitches regulate cytochrome c release in permeabilised cells
   Robert J. Mart, Rachel J. Errington, Catherine L. Watkins, Sally C. Chappell, Marie Wiltshire, Arwyn Tomos Jones, Paul J. Smith, Rudolf K. Allemann · 2013 · Molecular BioSystems
3. Noncovalent Peptide Stapling Using Alpha-Methyl- l -Phenylalanine for α-Helical Peptidomimetics
   Ross A. D. Bathgate, Praveen Praveen, Ashish Sethi, Werner Issao Furuya, Rishi R. Dhingra, Martina Kočan, Qinghao Ou, Adam L. Valkovic, Isis Gil‐Miravet, Mónica Navarro-Sánchez et al. · 2023 · Journal of the American Chemical Society
4. Insights into Modeling Approaches in Chemistry: Assessing Ligand‐Protein Binding Thermodynamics Based on Rigid‐Flexible Model Molecules
   Igor V. Komarov, Volodymyr Bugrov, Anton Cherednychenko, Oleksandr O. Grygorenko · 2023 · The Chemical Record
5. Discovery of novel inhibitors of anti-apoptotic Bcl-2 proteins derived from Bim BH3 domain
   Chuanliang Zhang, Shan Liu, Xiaochun Liu, Jiangming Gao, Shulin Wang · 2017 · Chinese Chemical Letters
6. Pharmaceutical Implications of Helix Length Control in Helix-Mediated Protein–Protein Interactions
   L.‐G. Milroy, Luc Brunsveld · 2013 · Future Medicinal Chemistry
7. Bridged α-helix mimetic small molecules
   Yeongju Lee, Haeri Im, Sanket Das, Misook Oh, Ji Hoon Lee, Sihyun Ham, Hyun‐Suk Lim · 2019 · Chemical Communications
8. Deciphering molecular specificity in MCL-1/BAK interaction and its implications for designing potent MCL-1 inhibitors
   Hudie Wei, Haolan Wang, Shuang Xiang, Jiaqi Wang, Lingzhi Qu, Xiaojuan Chen, Ming Guo, Xiaoyun Lu, Yongheng Chen · 2025 · Cell Death and Differentiation
9. Stapled peptides as potential therapeutics for diabetes and other metabolic diseases
   Dominika Nielipinska, Dominika Rubiak, Agnieszka J. Pietrzyk‐Brzezinska, Joanna Małolepsza, K. M. Błażewska, Edyta Gendaszewska‐Darmach · 2024 · Biomedicine & Pharmacotherapy
10. Macrocyclic α-Helical Peptide Drug Discovery
    Tomi K. Sawyer, Vincent Guerlavais, Krzysztof Darłak, Eric Feyfant · 2014 · Royal Society of Chemistry eBooks
11. Bcl-2 Protein Interplay on the Outer Mitochondrial Membrane
    Frank Edlich, Jean‐Claude Martinou · 2016 · Springer eBooks
12. N‐locking stabilization of covalent helical peptides: Application to Bfl‐1 antagonists
    Carlo Baggio, Parima Udompholkul, Luca Gambini, Jennifer N. Jossart, Ahmed F. Salem, M. Håkansson, J. Jefferson P. Perry, Maurizio Pellecchia · 2020 · Chemical Biology & Drug Design
13. Targeted Degradation of Protein Kinase A via a Stapled Peptide PROTAC
    Matthew K. Whittaker, George N. Bendzunas, Mahsa Shirani, Timothy J. LeClair, Bassem Shebl, Taylor C. Dill, Philip Coffino, Sanford M. Simon, Eileen J. Kennedy · 2024 · ACS Chemical Biology
14. The key position: influence of staple location on constrained peptide conformation and binding
    Kelly L. Keeling, Okki Cho, Denis B. Scanlon, Grant W. Booker, Andrew David Abell, Kate L. Wegener · 2016 · Organic & Biomolecular Chemistry
15. Receptor-templated stapling of intrinsically disordered peptide ligands
    Conor M. Haney, W. Seth Horne · 2015 · Organic & Biomolecular Chemistry
16. Extracellular Vesicle‐Mediated Delivery of Constrained Peptides Disrupts the Pathogenic Interaction of LRRK2‐FADD in Parkinson's Disease
    Yaochao Zheng, Brian J. Jurgielewicz, Leah G. Helton, Hardy J. Rideout, Eileen J. Kennedy, Steven Stice, Yao Yao · 2026 · Journal of Extracellular Biology
17. Molecular mechanisms underlying HRK interaction with BCL-XL and BCL-2 reveal specificity determinants for BH3 mimetics
    Jiaqi Wang, Ming Guo, Shuyan Dai, Hudie Wei · 2025 · iScience
18. Apoptosis as a Therapeutic Target in Chronic Lymphocytic Leukemia
    Christian Billard · 2015 · Lymphoma and Chronic Lymphocytic Leukemias
19. Interchain doubly-bridged α-helical peptides for the development of protein binders
    Yaqi Chen, Jingjing Liang, Tao Li, Ping J. Lin, Yibing Zhao, Chuanliu Wu · 2019 · Chinese Chemical Letters
20. Therapeutics targeting BCL2 family proteins
    Haiming Dai, X. Wei Meng, Kaiqin Ye, Jia Jia, Scott H. Kaufmann · 2021 · Elsevier eBooks
21. Inhibitory Potential and Binding Thermodynamics of Scyllatoxin‐Based BH3 Domain Mimetics Targeting Repressor BCL2 Proteins
    H. A. D. B. Amarasiri, Danushka Arachchige, Matthew J. K. Vince, Justin M. Holub · 2025 · Journal of Molecular Recognition
22. Hit evaluation of an α-helical peptide: Ala-scan, truncation and sidechain-to-sidechain macrocyclization of an RNA polymerase Inhibitor
    Ahmed A. M. Kamal, Monica M. W. Habib, Jörg Haupenthal, Rolf W. Hartmann, Martin Empting · 2019 · Biological Chemistry
23. Lead Generation for Challenging Targets
    Jinqiao Wan, Dengfeng Dou, Hongmei Song, Xian‐Hui Wu Xuemin Cheng, Jin Li · 2016 · Methods and principles in medicinal chemistry
24. Development of Stabilized Short Helical Peptides and Their Functionalization
    Yosuke Demizu, Takashi Misawa, Masaaki Kurihara · 2014 · Journal of Synthetic Organic Chemistry Japan
25. Peptide and Nonpeptide Approaches to Target Protein-protein Interactions for the Treatment of Cancer.
    Ran Xu · 2015 · Deep Blue (University of Michigan)
26. Structural plasticity of BCL-2 family proteins and its functional implication in apoptosis
    Minjoo Choi · 2018
27. Molecular Imaging Agent Design for Quantifying Beta Cell Mass in Type 1 Diabetes
    Liang Zhang · 2017 · Deep Blue (University of Michigan)
28. Macrocyclization of an all-D linear peptide improves target affinity and imparts cellular activity: A novel stapled alpha-helical peptide modality
    Shimin Jiang, Christopher John Brown · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
29. Hitting "Undruggable" Targets: Determining the Properties of Cell Penetrant Stabilized Peptide Therapeutics for Intracellular Targets
    Lydia Atangcho · 2020 · Deep Blue (University of Michigan)
30. 離島地域の中学校における地域学習の現状(その2) : 沖縄県与那国町を事例として
    貢 岩田 · 2011 · Institutional Repositories DataBase (IRDB)
31. Applications of Constrained Helices
    Zigang Li, Hui Zhao, Chuan Wan · 2021 · Wiley eBooks
32. Introduction
    Kuan Hu · 2021 · Springer theses
33. Properties of Stabilized Peptides
    Zigang Li, Hui Zhao, Chuan Wan · 2021
34. Macrocyclization of an all-D linear peptide improves target affinity and imparts cellular activity: A novel stapled α-helical peptide modality
    Srinivasaraghavan Kannan, Pietro G. A. Aronica, Simon Ng, Dawn Thean, Yuri Frosi, Sharon Min Qi Chee, Shimin Jiang, Tsz Ying Yuen, Ahmad Sadruddin, Hung Yi Kristal Kaan et al. · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
35. Molecular basis of BCL2L10/Nrh oncogenic activity in breast cancer
    Adrien Nougarède · 2016 · theses.fr (ABES)
36. BindingDB Entry 50009066: Consideration of Binding Kinetics in the Design of Stapled Peptide Mimics of the Disordered Proteins Eukaryotic Translation Initiation Factor 4E-Binding Protein 1 and Eukaryotic Translation Initiation Factor 4G.
    BindingDB · 2021 · UC San Diego
37. BindingDB Entry 50019884: Discovery of Sulanemadlin (ALRN-6924), the First Cell-Permeating, Stabilized α-Helical Peptide in Clinical Development.
    BindingDB · 2024 · UC San Diego
38. BindingDB Entry 50005476: Design of cell-permeable stapled peptides as HIV-1 integrase inhibitors.
    BindingDB · 2020 · UC San Diego
39. BindingDB Entry 7798: hBfl-1/hNOXA Interaction Studies Provide New Insights on the Role of Bfl-1 in Cancer Cell Resistance and for the Design of Novel Anticancer Agents.
    BindingDB · 2017 · UC San Diego
40. BindingDB Entry 50043721: TBA
    BindingDB · 2014 · UC San Diego
41. BindingDB Entry 50018637: Pharmacological Targeting of Executioner Proteins: Controlling Life and Death.
    BindingDB · 2024 · UC San Diego