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Application of Combinatorial Chemistry Science on Modern Drug Discovery
Abstract
The science that established combinatorial chemistry as important new discipline in the 1980s and 1990s has re-emerged and infiltrated every sub-discipline within modern drug discovery and has profound impact. The application of combinatorial chemistry science has revolutioned high-throughput screening paradigms, chemical lead optimization, library purification, and post-purification sample handling, as well as in vitro and in vivo drug metabolism and pharmacokinetic assays. Although no longer in the spotlight and heralded as the savior of the drug industry, “combinatorial chemistry” is alive and well; in fact, combinatorial chemistry science is more prevalent and wide-spread than ever before.
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Citations
Cited by
The Current State of Peptide Drug Discovery: Back to the Future?
Henninot, A., Collins, J. C., & Nuss, J. M. (2018) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.7b00318 · Cited by 1,113
Galloway, W. R. J. D., Isidro-Llobet, A., & Spring, D. R. (2010) · Nature Communications · doi:10.1038/ncomms1081 · Cited by 891
Big data and artificial intelligence modeling for drug discovery
Zhu, H. (2020) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010919-023324 · Cited by 455
Constrained quantum optimization for extractive summarization on a trapped-ion quantum computer
Niroula, P., Shaydulin, R., Yalovetzky, R., Minssen, P., Herman, D., Hu, S., & Pistoia, M. (2022) · Scientific Reports · doi:10.1038/s41598-022-20853-w · Cited by 59
Metadata
- Authors
- Kennedy, J. P., Williams, L., Bridges, T. M., Daniels, R. N., Weaver, D., & Lindsley, C. W.
- Venue
- Journal of Combinatorial Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-01-26
- Volume
- 10
- Issue
- 3
- Pages
- 345-354
- ISSN
- 1520-4766 (ISSN-L)
- 1520-4774
- OpenAlex
- W1979142801
- Cited by
- 213
- References
- 0
- FWCI
- 9.68
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Application of Combinatorial Chemistry Science on Modern Drug Discovery. https://app.cochat.ai/papers/10.1021/cc700187t
- The paper
- Kennedy, J. P., Williams, L., Bridges, T. M., Daniels, R. N., Weaver, D., & Lindsley, C. W. (2008). Application of Combinatorial Chemistry Science on Modern Drug Discovery. Journal of Combinatorial Chemistry. https://doi.org/10.1021/cc700187t
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
