The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Peptide Controls on Calcite Mineralization: Polyaspartate Chain Length Affects Growth Kinetics and Acts as a Stereochemical Switch on Morphology
Abstract
Polyaspartate domains are a prominent feature of proteins associated with biogenic carbonates and have been implicated in modifying crystal morphology through specific interactions with step edges. Here, we show that the morphology and growth kinetics of calcite are modified in a systematic way when a series of poly- l -aspartates, Asp 1 - 6, are introduced into solution. In-situ measurements of step propagation rates by atomic force microscopy reveal these effects are strongly chain-length dependent and specific to the crystallographically distinct, obtuse and acute step types. Direct observations of differential roughening and rounding of the step edges demonstrate that, while Asp 1 and Asp 2 have stronger effects on acute step edges, a crossover occurs for the longer Asp 4,5,6 peptides that preferentially affect obtuse steps. Independent analysis of Asp n −step edge interactions by semiempirical quantum mechanical modeling gives estimates of aspartate−step edge binding energies and predicts that the crossover should occur at n = 2. The switch occurs because, upon Asp n binding, the energy required to dehydrate acute steps is greater than that at the obtuse steps when n = 3−6. Step velocity measurements show that the concentration of Asp n needed to stop growth scales exponentially and inversely with the calculated binding energies. A simple model of Asp n adsorption to the steps is derived from these results. These findings suggest a process by which small fluctuations in primary structure in proteins can control calcite shape.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Greater negative charge density associated with longer peptides is more efficient at promoting Ca ion dehydration kinetics.
“while the greater negative charge density associated with longer peptides is more efficient at promoting Ca ion dehydration kinetics (Elhadj et al., 2006).”
From Inorganic synthesis of Fe–Ca–Mg carbonates at low temperature (2009) · cites this paper as Elhadj et al., 2006
Citations
Cites
Sreerama, N., & Woody, R. W. (2000) · Analytical Biochemistry · doi:10.1006/abio.2000.4880 · Cited by 2,997
Dauber‐Osguthorpe, P., Roberts, V. A., Osguthorpe, D. J., Wolff, J. A., Genest, M., & Hagler, A. T. (1988) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.340040106 · Cited by 2,075
Interactions between acidic proteins and crystals: stereochemical requirements in biomineralization.
Addadi, L., & Weiner, S. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.12.4110 · Cited by 1,089
Andrade, M. A., Chacón, P., Merelo, J. J., & Morán, F. (1993) · Protein Engineering Design and Selection · doi:10.1093/protein/6.4.383 · Cited by 1,007
Past temperature and δ18O of surface ocean waters inferred from foraminiferal Mg/Ca ratios
Elderfield, H., & Ganssen, G. M. (2000) · Nature · doi:10.1038/35013033 · Cited by 773
Formation of chiral morphologies through selective binding of amino acids to calcite surface steps
Orme, C. A., Noy, A., Wierzbicki, A., McBride, M. T., Grantham, M., Teng, H. H., Dove, P. M., & DeYoreo, J. J. (2001) · Nature · doi:10.1038/35081034 · Cited by 700
Self-citationThermodynamics of Calcite Growth: Baseline for Understanding Biomineral Formation
Teng, H. H., Dove, P. M., Orme, C. A., & De Yoreo, J. J. (1998) · Science · doi:10.1126/science.282.5389.724 · Cited by 490
Self-citationKinetics of calcite growth: surface processes and relationships to macroscopic rate laws
Teng, H. H., Dove, P. M., & Yoreo, J. J. D. (2000) · Geochimica et Cosmochimica Acta · doi:10.1016/s0016-7037(00)00341-0 · Cited by 443
Self-citationBiomineralization and biomimetic materials chemistry
Mann, S. (1995) · Journal of Materials Chemistry · doi:10.1039/jm9950500935 · Cited by 248
Gotliv, B., Kessler, N., Sumerel, J. L., Morse, D. E., Tuross, N., Addadi, L., & Weiner, S. (2005) · ChemBioChem · doi:10.1002/cbic.200400221 · Cited by 243
An in-situ AFM investigation of canavalin crystallization kinetics
Land, T. A., Yoreo, J. J. D., & Lee, J. D. (1997) · Surface Science · doi:10.1016/s0039-6028(97)00187-8 · Cited by 160
Surface Atomic Structure of KDP Crystals in Aqueous Solution: An Explanation of the Growth Shape
de Vries, S. A., Goedtkindt, P., Bennett, S. L., Huisman, W. J., Zwanenburg, M. J., Smilgies, D., Yoreo, J. J. D., van Enckevort, W. J. P., Bennema, P., & Vlieg, E. (1998) · Physical Review Letters · doi:10.1103/physrevlett.80.2229 · Cited by 148
Crystal-protein interactions studied by overgrowth of calcite on biogenic skeletal elements
Aizenberg, J., Albeck, S., Weiner, S., & Addadi, L. (1994) · Journal of Crystal Growth · doi:10.1016/0022-0248(94)90283-6 · Cited by 132
Reversed calcite morphologies induced by microscopic growth kinetics: insight into biomineralization
Teng, H. H., Dove, P. M., & DeYoreo, J. J. (1999) · Geochimica et Cosmochimica Acta · doi:10.1016/s0016-7037(99)00103-9 · Cited by 127
Self-citationWeiner, S. (1983) · Biochemistry · doi:10.1021/bi00286a023 · Cited by 114
Slow differential rotation of the Earth's inner core indicated by temporal changes in scattering
Vidale, J. E., Dodge, D. A., & Earle, P. S. (2000) · Nature · doi:10.1038/35013039 · Cited by 113
Evidence for fault weakness and fluid flow within an active low-angle normal fault
Floyd, J. S., Mutter, J. C., Goodliffe, A. M., & Taylor, B. (2001) · Nature · doi:10.1038/35081040 · Cited by 110
A Computer Modeling Study of the Inhibiting Effect of Organic Adsorbates on Calcite Crystal Growth
de Leeuw, N. H., & Cooper, T. G. (2003) · Crystal Growth & Design · doi:10.1021/cg0341003 · Cited by 105
Effect of trace metal availability on coccolithophorid calcification
Schulz, K. G., Zondervan, I., Gerringa, L. J. A., Timmermans, K. R., Veldhuis, M. J. W., & Riebesell, U. (2004) · Nature · doi:10.1038/nature02631 · Cited by 91
Mechanism of Calcite Crystal Growth Inhibition by the N-terminal Undecapeptide of Lithostathine
Gerbaud, V., Pignol, D., Loret, E. P., Bertrand, J. A., Berland, Y., Fontecilla-Camps, J. C., Canselier, J. P., Gabas, N., & Verdier, J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.2.1057 · Cited by 79
Falini, G., Fermani, S., Gazzano, M., & Ripamonti, A. (2000) · Journal of the Chemical Society Dalton Transactions · doi:10.1039/b003334k · Cited by 78
Fenter, P., & Sturchio, N. C. (1999) · Geochimica et Cosmochimica Acta · doi:10.1016/s0016-7037(99)00241-0 · Cited by 60
Budair, M. O., Khan, M. S., Zubair, S. M., et al. (1998) · Heat and Mass Transfer · doi:10.1007/s002310050245 · Cited by 25
Characterization of the Bone Sialoprotein (BSP) Gene Promoter
Sodek, J., Li, J. J., Kim, R. H., Ogata, Y., & Yamauchp, M. (1996) · Connective Tissue Research · doi:10.3109/03008209609029171 · Cited by 19
Flagged first, then by citations
Research works printed but not linked: 12
- Makarov V. N., 2001, Russ. J. Inorg. Chem., 46, 1654
- Moore E. W., 1987, Am. J. Physiol., 252, G718
- Addadi L., 1990, Croat. Chem. Acta, 63, 544
- Falini G., 2000, J. Chem. Soc., Dalton Trans., 3983, 3987
- Land T. A., 1997, Surf. Sci., 384, 155
- Teng H. H., 1999, J. Geochim. Cosmochim. Acta, 63, 2512
- Teng H. H., 2000, J. Geochim. Cosmochim. Acta, 64, 2266
- Sreerama N., 2000, Anal. Biochem., 287, 60
- Dauberosguthorpe P., 1988, Proteins, 4, 47
- de Vries S. A., 1998, Phys. Rev. Lett., 80, 2232
- Teng H. H., 1998, J. Science, 282, 727
- Fu G., J. Adv. Mater., in press.
Cited by
Sorted by citations
Controlling Mineral Morphologies and Structures in Biological and Synthetic Systems
Meldrum, F. C., & Cölfen, H. (2008) · Chemical Reviews · doi:10.1021/cr8002856 · Cited by 1,397
Mineral surfaces, geochemical complexities, and the origins of life
Hazen, R. M., & Sverjensky, D. A. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a002162 · Cited by 344
Role of molecular charge and hydrophilicity in regulating the kinetics of crystal growth
Elhadj, S., De Yoreo, J. J., Hoyer, J. R., & Dove, P. M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605748103 · Cited by 270
Self-citationDe Yoreo, J. J., Zepeda-Ruiz, L. A., Friddle, R. W., Qiu, S. R., Wasylenki, L. E., Chernov, A. A., Gilmer, G. H., & Dove, P. M. (2009) · Crystal Growth & Design · doi:10.1021/cg900543g · Cited by 188
Self-citationMagnesium-aspartate-based crystallization switch inspired from shell molt of crustacean
Tao, J., Zhou, D., Zhang, Z., Xu, X., & Tang, R. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909040106 · Cited by 141
Engineered Biomimetic Polymers as Tunable Agents for Controlling CaCO3 Mineralization
Chen, C.-L., Qi, J., Zuckermann, R. N., & DeYoreo, J. J. (2011) · Journal of the American Chemical Society · doi:10.1021/ja200595f · Cited by 121
Self-citationIhli, J., Kim, Y., Noel, E. H., & Meldrum, F. C. (2013) · Advanced Functional Materials · doi:10.1002/adfm.201201805 · Cited by 119
Inorganic synthesis of Fe–Ca–Mg carbonates at low temperature
Romanek, C. S., Jiménez-López, C., Navarro, A. R., Sánchez-Román, M., Sahai, N., & Coleman, M. (2009) · Geochimica et Cosmochimica Acta · doi:10.1016/j.gca.2009.05.065 · Cited by 94
“…work, polyaspartate peptide with a negative charge has been found to promote the incorporation of Mg into calcite (Stephenson et al., 2008), while the greater negative charge density associated with longer peptides is more efficient at promoting Ca ion dehydration kinetics (Elhadj et al., 2006).”
BackgroundChiral and Achiral Mechanisms of Regulation of Calcite Crystallization
Maruyama, M., Tsukamoto, K., Sazaki, G., Nishimura, Y., & Vekilov, P. G. (2009) · Crystal Growth & Design · doi:10.1021/cg701219h · Cited by 40
Keller, K. S., Olsson, M. H. M., Yang, M., & Stipp, S. L. S. (2015) · Langmuir · doi:10.1021/la504319z · Cited by 39
Magnesite growth inhibition by organic ligands: An experimental study at 100, 120 and 146 °C
Gautier, Q., Bénézeth, P., & Schott, J. (2016) · Geochimica et Cosmochimica Acta · doi:10.1016/j.gca.2016.02.028 · Cited by 26
Metadata
- Authors
- Elhadj, S., Salter, E. A., Wierzbicki, A., De Yoreo, J. J., Han, N., & Dove, P. M.
- Affiliations
- Lawrence Livermore National Laboratory (US)
- Department of Geosciences, Virginia Tech, Derring Hall, Blacksburg, Virginia 24061, Department of Chemistry, University of South Alabama, Mobile, Alabama 36688, and Department of Chemistry and Materials Science, Lawrence Livermore National Laboratory, P.O. Box 808, Livermore, California 94551
- Corresponding author
- Elhadj, S.
- Venue
- Crystal Growth & Design
- Publisher
- American Chemical Society (ACS)
- Published
- 2005-09-21
- Volume
- 6
- Issue
- 1
- Pages
- 197-201
- ISSN
- 1528-7483 (ISSN-L)
- 1528-7505
- OpenAlex
- W2150295685
- Cited by
- 165
- References
- 24
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 6 · 2023: 4 · 2022: 9 · 2021: 5 · 2020: 9 · 2019: 4 · 2018: 8 · 2017: 7 · 2016: 4 · 2015: 8 · 2014: 8 · 2013: 15 · 2012: 19
- FWCI
- 3.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Crystal Growth & Design (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Calcium Carbonate Crystallization and Inhibition
- Physical Sciences › Materials Science › Materials Chemistry › Crystallization and Solubility Studies
- Physical Sciences › Environmental Science › Environmental Engineering › Microbial Applications in Construction Materials
- Keywords
- polyaspartate, calcite crystal growth, crystal morphology, step propagation, chain length dependence, peptide adsorption, biomineralization, crystal growth kinetics, binding energy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
