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Influences of Material Characteristics on Ibuprofen Drug Loading and Release Profiles from Ordered Micro- and Mesoporous Silica Matrices
Abstract
A series of mesoscopically ordered silicas with different pore sizes, pore connectivity, and pore geometry have been studied as carrier matrices for controlled drug delivery systems. Ibuprofen was used as a model drug, and the release processes were monitored under in vitro conditions. The adsorption of ibuprofen from hexane was shown to be of Langmuir type in all cases, and the degree of drug loading was dependent on the specific surface area and the pore diameter of the host matrix. The release process is found to be mainly diffusion controlled, but clear differences were observed between the studied materials, which we mainly ascribe to differences in the pore connectivity and pore geometry of the materials, and the aqueous stability of the matrix. The studied nanostructured silicas display a high degree of drug loading, and, depending on the host material, a controlled drug release can be provided for time periods varying from hours to weeks.
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Cites
Ordered porous materials for emerging applications
Davis, M. E. (2002) · Nature · doi:10.1038/nature00785 · Cited by 5,308
Polymeric systems for controlled drug release
Uhrich, K. E., Cannizzaro, S. M., Langer, R. S., & Shakesheff, K. M. (1999) · Chemical Reviews · doi:10.1021/cr940351u · Cited by 2,633
Cited by
Ordered mesoporous materials for drug delivery
Wang, S. (2009) · Microporous and Mesoporous Materials · doi:10.1016/j.micromeso.2008.07.002 · Cited by 678
Yang, Q., Wang, S., Fan, P., Wang, L., Di, Y., Lin, K., & Xiao, F.-S. (2005) · Chemistry of Materials · doi:10.1021/cm051198v · Cited by 490
Yah, W. O., Takahara, A., & Lvov, Y. M. (2012) · Journal of the American Chemical Society · doi:10.1021/ja210258y · Cited by 429
Revisiting silica based ordered mesoporous materials: medical applications
Vallet-Regí, M., Ruiz-González, L., Izquierdo-Barba, I., & González-Calbet, J. M. (2006) · J. Mater. Chem. · doi:10.1039/b509744d · Cited by 326
Physicochemical characterization of drug nanocarriers
Berbel Manaia, E., Paiva Abuçafy, M., Chiari-Andréo, B. G., Lallo Silva, B., Oshiro-Júnior, J. A., & Chiavacci, L. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s133832 · Cited by 207
Metadata
- Authors
- Andersson, J., Rosenholm, J., Areva, S., & Lindén, M.
- Venue
- Chemistry of Materials
- Publisher
- American Chemical Society (ACS)
- Published
- 2004-09-22
- Volume
- 16
- Issue
- 21
- Pages
- 4160-4167
- ISSN
- 0897-4756 (ISSN-L)
- 1520-5002
- OpenAlex
- W2095407037
- Cited by
- 605
- References
- 2
- FWCI
- 11.87
- Type
- journal article
- Language
- en
- Open access
- closed
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- Andersson, J., Rosenholm, J., Areva, S., & Lindén, M. (2004). Influences of Material Characteristics on Ibuprofen Drug Loading and Release Profiles from Ordered Micro- and Mesoporous Silica Matrices. Chemistry of Materials. https://doi.org/10.1021/cm0401490
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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