The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Poly(methacrylic acid) Hydrogel Films and Capsules: Response to pH and Ionic Strength, and Encapsulation of Macromolecules
Abstract
Hydrogen-bonded multilayers of a neutral polymer (poly( N -vinylpyrrolidone), PVPON) with poly(methacrylic acid) (PMAA) were used as templates to introduce cross-links between PMAA layers using carbodiimide chemistry and ethylenediamine as a cross-linking agent. Upon exposure to high pH, PVPON is completely released from the hydrogel matrix, producing surface-attached PMAA hydrogels. When such hydrogels are deposited at the surface of silica particles, and the particle core is subsequently dissolved, hollow one-component hydrogel capsules are produced. PMAA hydrogel films and hollow capsules underwent reversible, large (factors of 2 or 3) changes in size in response to changes in solution pH and/or ionic strength. The capsules were used for entrapment and storage of macromolecules such as 500 kDa FITC-dextran by “locking” the capsule wall with an electrostatically associating polycation, poly- N -ethyl-4-vinylpyridinium bromide (QPVP). The release of the encapsulated macromolecules was achieved under high salt concentrations (0.6 M NaCl) when QPVP dissociated from the capsule wall. The pH and salt response of these PMAA hydrogel capsules and the polycation-controlled encapsulation of macromolecules hold promise for applications in biomedicine and biotechnology.
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Cites
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The Hydrodynamic Radii of Macromolecules and Their Effect on Red Blood Cell Aggregation
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Matrix Polyelectrolyte Microcapsules: New System for Macromolecule Encapsulation
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Protein Encapsulation via Porous CaCO3 Microparticles Templating
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Enzyme Encapsulation in Layer-by-Layer Engineered Polymer Multilayer Capsules
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Layered, Erasable Polymer Multilayers Formed by Hydrogen-Bonded Sequential Self-Assembly
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Self-citationEquilibrium swelling behavior of pH-sensitive hydrogels
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Cited by
Next generation, sequentially assembled ultrathin films: beyond electrostatics
Quinn, J. F., Johnston, A. P. R., Such, G. K., Zelikin, A. N., & Caruso, F. (2007) · Chemical Society Reviews · doi:10.1039/b610778h · Cited by 451
Layer‐by‐Layer Hydrogen‐Bonded Polymer Films: From Fundamentals to Applications
Kharlampieva, E., Kozlovskaya, V., & Sukhishvili, S. A. (2009) · Advanced Materials · doi:10.1002/adma.200803653 · Cited by 409
Self-citationProtein–polyelectrolyte interactions
Kayitmazer, A. B., Seeman, D., Minsky, B. B., Dubin, P. L., & Xu, Y. (2013) · Soft Matter · doi:10.1039/c2sm27002a · Cited by 406
pH-triggered shape response of cubical ultrathin hydrogel capsules
Kozlovskaya, V., Wang, Y., Higgins, W., Chen, J., Chen, Y., & Kharlampieva, E. (2012) · Soft Matter · doi:10.1039/c2sm25641j · Cited by 53
Self-citation
Metadata
- Authors
- Kozlovskaya, V., Kharlampieva, E., Mansfield, M. L., & Sukhishvili, S. A.
- Venue
- Chemistry of Materials
- Publisher
- American Chemical Society (ACS)
- Published
- 2005-12-17
- Volume
- 18
- Issue
- 2
- Pages
- 328-336
- ISSN
- 0897-4756 (ISSN-L)
- 1520-5002
- OpenAlex
- W2056126543
- Cited by
- 254
- References
- 25
- FWCI
- 5.52
- Type
- journal article
- Language
- en
- Open access
- closed
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