The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Theoretical Perspective on the Structure and Mechanism of Cytochrome P450 Enzymes
Abstract
A theoretical perspective on the structure and mechanisms of cytochrome P450 enzymes is given. Theoretical analyses based on quantum mechanical and hybrid quantum mechanical/molecular mechanical methods that allow the study of the active species in their native protein environment are discussed. Furthermore, a brief summary of the available theoretical methods is presented as well as the various species in the catalytic cycle and the principal mechanisms by which the enzyme transfers oxygen to the organic substrates.
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Citations
Cites
Crystal structure of the cytochrome P-450CAM active site mutant Thr252Ala
Raag, R., Martinis, S. A., Sligar, S. G., & Poulos, T. L. (1991) · Biochemistry · doi:10.1021/bi00112a008 · Cited by 208
Cited by
P450 Enzymes: Their Structure, Reactivity, and Selectivity—Modeled by QM/MM Calculations
Shaik, S., Cohen, S., Wang, Y., Chen, H., Kumar, D., & Thiel, W. (2010) · Chemical Reviews · doi:10.1021/cr900121s · Cited by 1,083
Self-citationReactivity of High-Valent Iron–Oxo Species in Enzymes and Synthetic Reagents: A Tale of Many States
Shaik, S., Hirao, H., & Kumar, D. (2007) · Accounts of Chemical Research · doi:10.1021/ar600042c · Cited by 555
Self-citationComplex reactions catalyzed by cytochrome P450 enzymes
Isin, E. M., & Guengerich, F. P. (2007) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2006.07.003 · Cited by 448
Yang, Y., Yu, H., York, D., Cui, Q., & Elstner, M. (2007) · The Journal of Physical Chemistry A · doi:10.1021/jp074167r · Cited by 317
Mast, N., Annalora, A. J., Lodowski, D. T., Palczewski, K., Stout, C. D., & Pikuleva, I. A. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.188433 · Cited by 138
Metadata
- Authors
- Shaik, S., Kumar, D., de Visser, S. P., Altun, A., & Thiel, W.
- Venue
- Chemical Reviews
- Publisher
- American Chemical Society (ACS)
- Published
- 2005-03-17
- Volume
- 105
- Issue
- 6
- Pages
- 2279-2328
- ISSN
- 0009-2665 (ISSN-L)
- 1520-6890
- OpenAlex
- W2100032379
- Cited by
- 1,236
- References
- 1
- FWCI
- 3.60
- Type
- journal article
- Language
- en
- Open access
- closed
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- Shaik, S., Kumar, D., de Visser, S. P., Altun, A., & Thiel, W. (2005). Theoretical Perspective on the Structure and Mechanism of Cytochrome P450 Enzymes. Chemical Reviews. https://doi.org/10.1021/cr030722j
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
