Sphingolipid and Glycosphingolipid Metabolic Pathways in the Era of Sphingolipidomics

Ceramide synthase 1 is regulated by proteasomal mediated turnover

Sridevi, P., Alexander, H., Laviad, E. L., Pewzner‐Jung, Y., Hannink, M., Futerman, A. H., & Alexander, S. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2009.04.006 · Cited by 53

Systems glycobiology: biochemical reaction networks regulating glycan structure and function

Neelamegham, S., & Liu, G. (2011) · Glycobiology · doi:10.1093/glycob/cwr036 · Cited by 53

Structural Profiling and Quantification of Sphingomyelin in Human Breast Milk by HPLC-MS/MS

Blaas, N., Niimi, C., Bartke, N., Stahl, B., & Humpf, H. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf200943n · Cited by 53

Revealing a signaling role of phytosphingosine‐1‐phosphate in yeast

Cowart, L. A., Shotwell, M. S., Worley, M. L., Richards, A., Montefusco, D. J., Hannun, Y. A., & Lu, X. (2010) · Molecular Systems Biology · doi:10.1038/msb.2010.3 · Cited by 52

Specificity of the Dihydroceramide Desaturase Inhibitor N-[(1R,2S)-2-Hydroxy-1-hydroxymethyl-2-(2-tridecyl-1-cyclopropenyl)ethyl]octanamide (GT11) in Primary Cultured Cerebellar Neurons

Triola, G., Fabriàs, G., Dragusin, M., Niederhausen, L., Broere, R., Llebaria, A., & van Echten‐Deckert, G. (2004) · Molecular Pharmacology · doi:10.1124/mol.104.003681 · Cited by 52

Alkaline Ceramidase 2 (ACER2) and Its Product Dihydrosphingosine Mediate the Cytotoxicity of N-(4-Hydroxyphenyl)retinamide in Tumor Cells

Mao, Z., Sun, W., Xu, R., Novgorodov, S. A., Szulc, Z. M., Bielawski, J., Obeid, L. M., & Mao, C. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.105296 · Cited by 51

The ω-hydroxyceramides of pig epidermis are attached to corneocytes solely through ω-hydroxyl groups

Stewart, M. E., & Downing, D. T. (2001) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)31600-x · Cited by 51

Myristic acid increases the activity of dihydroceramide Δ4-desaturase 1 through its N-terminal myristoylation

Beauchamp, E., Goenaga, D., Bloc’h, J. L., Catheline, D., Legrand, P., & Rioux, V. (2007) · Biochimie · doi:10.1016/j.biochi.2007.07.001 · Cited by 50

A novel mechanism of dasatinib-induced apoptosis in chronic myeloid leukemia; ceramide synthase and ceramide clearance genes

Akçok, E. B. G., Ural, A. U., Avcu, F., & Baran, Y. (2011) · Annals of Hematology · doi:10.1007/s00277-011-1212-5 · Cited by 50

Integration of lipidomics and transcriptomics data towards a systems biology model of sphingolipid metabolism

Gupta, S., Maurya, M. R., Merrill, A. H., Glass, C. K., & Subramaniam, S. (2011) · BMC Systems Biology · doi:10.1186/1752-0509-5-26 · Cited by 50

Stress-induced ER to Golgi translocation of ceramide synthase 1 is dependent on proteasomal processing

Sridevi, P., Alexander, H., Laviad, E. L., Min, J., Mesika, A., Hannink, M., Futerman, A. H., & Alexander, S. (2009) · Experimental Cell Research · doi:10.1016/j.yexcr.2009.09.027 · Cited by 50

Cell surface sphingolipid glycohydrolases in neuronal differentiation and aging in culture

Aureli, M., Loberto, N., Lanteri, P., Chigorno, V., Prinetti, A., & Sonnino, S. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.07019.x · Cited by 49

Structural Insights into the Enzymatic Mechanism of Serine Palmitoyltransferase from Sphingobacterium multivorum

Ikushiro, H., Islam, M. M., Okamoto, A., Hoseki, J., Murakawa, T., Fujii, S., MIYAHARA, I., & Hayashi, H. (2009) · The Journal of Biochemistry · doi:10.1093/jb/mvp100 · Cited by 49

Sphingomyelin synthase 2 (SMS2) deficiency attenuates LPS-induced lung injury

Gowda, S., Yeang, C., Wadgaonkar, S., Anjum, F., Grinkina, N., Cutaia, M. V., Jiang, X.-C., & Wadgaonkar, R. (2010) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00208.2010 · Cited by 49

Identification and characterization by electrospray mass spectrometry of endogenous Drosophila sphingadienes

Fyrst, H., Zhang, X., Herr, D. R., Byun, H. S., Bittman, R., Phan, V. H., Harris, G. L., & Saba, J. D. (2007) · Journal of Lipid Research · doi:10.1194/jlr.m700414-jlr200 · Cited by 49

Quantitative measurement of different ceramide species from crude cellular extracts by normal‐phase high‐performance liquid chromatography coupled to atmospheric pressure ionization mass spectrometry

Pettus, B. J., Kroesen, B., Szulc, Z. M., Bielawska, A., Bielawski, J., Hannun, Y. A., & Busman, M. (2004) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.1373 · Cited by 49

Glucosphingolipid dependence of hormone-stimulated inositol trisphosphate formation.

Shayman, J. A., Mahdiyoun, S., Deshmukh, G., Barcelon, F. S., Inokuchi, J., & Radin, N. S. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)38320-6 · Cited by 48

The way we view cellular (glyco)sphingolipids

Hoetzl, S., Sprong, H., & Gerrit van, M. E. E. R. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04721.x · Cited by 48

Distribution of cholesterol and galactosylceramide in rat cerebellar white matter

Börner, K., NYGREN, H., Hagenhoff, B., Malmberg, P., Tallarek, E., & Månsson, J. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2006.02.021 · Cited by 48

Induction of sialic acid 9-O-acetylation by diverse gene products: Implications for the expression cloning of sialic acid O-acetyltransferases

Shi, W.-X., Chammas, R. J., & Varki, A. P. (1998) · Glycobiology · doi:10.1093/glycob/8.2.199 · Cited by 48

Mitochondrially targeted ceramides preferentially promote autophagy, retard cell growth, and induce apoptosis

Hou, Q., Jin, J., Zhou, H., Novgorodov, S. A., Bielawska, A. E., Szulc, Z. M., Hannun, Y. A., Obeid, L. M., & Hsu, Y. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m012161 · Cited by 48

First Asymmetric Synthesis of 6-Hydroxy-4-Sphingenine-Containing Ceramides. Use of Chiral Propargylic Alcohols To Prepare a Lipid Found in Human Skin

Chun, J., Byun, H., & Bittman, R. (2002) · The Journal of Organic Chemistry · doi:10.1021/jo026240+ · Cited by 47

Sphingosine kinases, sphingosine-1-phosphate and sphingolipidomics

Maceyka, M. W., Milstien, S., & Spiegel, S. (2004) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2004.09.010 · Cited by 47

A lipid binding domain in sphingosine kinase 2

Don, A. S., & Rosen, H. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.01.075 · Cited by 47

Observation of different ceramide species from crude cellular extracts by normal‐phase high‐performance liquid chromatography coupled to atmospheric pressure chemical ionization mass spectrometry

Pettus, B. J., Bielawska, A., Kroesen, B., et al. (2003) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.1043 · Cited by 47

Rapid demonstration of diversity of sulfatide molecular species from biological materials by MALDI-TOF MS

Kyogashima, M., Tamiya‐Koizumi, K., Ehara, T., Li, G., Hu, R., Hara, A., Aoyama, T., & Kannagi, R. (2006) · Glycobiology · doi:10.1093/glycob/cwj122 · Cited by 47

Differential targeting of glucosylceramide and galactosylceramide analogues after synthesis but not during transcytosis in Madin-Darby canine kidney cells.

van Genderen, I., & Gerrit van, M. E. E. R. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.131.3.645 · Cited by 47

Free Sphingosines of Human Skin Include 6-Hydroxysphingosine and Unusually Long-Chain Dihydrosphingosines

Stewart, M. E., & Downing, D. T. (1995) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12323736 · Cited by 46

Integrated mass spectrometric strategy for characterizing the glycans from glycosphingolipids and glycoproteins: direct identification of sialyl Lex in mice

Parry, S., Ledger, V., Tissot, B., Haslam, S. M., Scott, J., Morris, H. R., & Dell, A. (2007) · Glycobiology · doi:10.1093/glycob/cwm024 · Cited by 46

Mathematical modeling of pathogenicity of Cryptococcus neoformans

García, J., Shea, J. M., Alvarez‐Vasquez, F., Qureshi, A., Luberto, C., Voit, E. O., & Poeta, M. D. (2008) · Molecular Systems Biology · doi:10.1038/msb.2008.17 · Cited by 46

Comprehensive analysis of glycosyltransferases in eukaryotic genomes for structural and functional characterization of glycans

Hashimoto, K., Tokimatsu, T., Kawano, S., Yoshizawa, A. C., Okuda, S., Goto, S., & Kanehisa, M. I. (2009) · Carbohydrate Research · doi:10.1016/j.carres.2009.03.001 · Cited by 45

Synthesis of a Cyclopropene Analogue of Ceramide, a Potent Inhibitor of Dihydroceramide Desaturase

Triola, G., Fabriàs, G., & Llebaria, A. (2001) · Angewandte Chemie International Edition · Cited by 45

Reversal of non‐hydroxy : α‐hydroxy galactosylceramide ratio and unstable myelin in transgenic mice overexpressing UDP‐galactose : ceramide galactosyltransferase

Fewou, S. N., Büssow, H., Schaeren‐Wiemers, N., Vanier, M. T., Macklin, W. B., Gieselmann, V., & Eckhardt, M. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03221.x · Cited by 45

Analysis of sphingolipids in potatoes (Solanum tuberosum L.) and sweet potatoes (Ipomoea batatas (L.) Lam.) by reversed phase high‐performance liquid chromatography electrospray ionization tandem mass spectrometry (HPLC‐ESI‐MS/MS)

Bartke, N., Fischbeck, A., & Humpf, H. (2006) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200600140 · Cited by 45

Fine tuning of cell functions through remodeling of glycosphingolipids by plasma membrane‐associated glycohydrolases

Sonnino, S., Aureli, M., Loberto, N., Chigorno, V., & Prinetti, A. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.11.020 · Cited by 44

Flux of the l-Serine Metabolism in Rat Liver

Xue, H., Fujie, M., Sakaguchi, T., Oda, T., Ogawa, H., Kneer, N. M., Lardy, H. A., & Ichiyama, A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.23.16020 · Cited by 44

Decreased fumonisin hepatotoxicity in mice with a targeted deletion of tumor necrosis factor receptor 1

Sharma, R. P., Bhandari, N., He, Q., Riley, R. T., & Voss, K. A. (2001) · Toxicology · doi:10.1016/s0300-483x(00)00405-4 · Cited by 43

Cycloserine and threo-dihydrosphingosine inhibit TNF-α-induced cytotoxicity: evidence for the importance of de novo ceramide synthesis in TNF-α signaling

Meyer, S. G. E., & de GROOT, H. (2003) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2003.10.002 · Cited by 42

Intracellular localization of sphingosine kinase 1 alters access to substrate pools but does not affect the degradative fate of sphingosine-1-phosphate

Siow, D. L., Anderson, C. D., Berdyshev, E. V., Skobeleva, A., Pitson, S. M., & Wattenberg, B. W. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m004374 · Cited by 42

Shiga Toxin Increases Formation of Clathrin-Coated Pits through Syk Kinase

Utskarpen, A., Massol, R., van Deurs, B., Lauvrak, S. U., Kirchhausen, T. L., & Sandvig, K. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010944 · Cited by 42

Role of Sphingomyelin Synthase in Controlling the Antimicrobial Activity of Neutrophils against Cryptococcus neoformans

Qureshi, A., Subathra, M., Grey, A., Schey, K., Del Poeta, M., & Luberto, C. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015587 · Cited by 41

Physiopathological function of hematoside (GM3 ganglioside)

Inokuchi, J. (2011) · Proceedings of the Japan Academy Series B · doi:10.2183/pjab.87.179 · Cited by 40

L‐selectin and its ligands mediate infiltration of mononuclear cells into kidney interstitium after ureteric obstruction

Shikata, K., Suzuki, Y., Wada, J., Hirata, K., Matsuda, M., Kawashima, H., Suzuki, T., Iizuka, M., Makino, H., & Miyasaka, M. (1999) · The Journal of Pathology · doi:10.1002/(sici)1096-9896(199905)188:1<93::aid-path305>3.0.co;2-# · Cited by 40

Biosynthesis of Sphingolipids in Plants (and Some of Their Functions)

Zäuner, S., Ternes, P., & Warnecke, D. C. (2010) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-6741-1_18 · Cited by 39

Apoptosis Occurs via the Ceramide Recycling Pathway in Human HaCaT Keratinocytes

Takeda, S., Mitsutake, S., Tsuji, K., et al. (2006) · The Journal of Biochemistry · doi:10.1093/jb/mvj026 · Cited by 39

The clinical potential of sphingolipid-based therapeutics

Fox, T. E., Finnegan, C. M., Blumenthal, R., & KESTER, M. A. (2006) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-005-5543-z · Cited by 38

The synthesis of sphingomyelin in the Morris hepatomas 7777 and 5123D is restricted to the plasma membrane

van den Hill, A., van Heusden, G. P. H., & WIRTZ, K. W. A. (1985) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(85)90210-3 · Cited by 37

Signalling functions for sphingolipid long-chain bases in Saccharomyces cerevisiae

Liu, K., Zhang, X., Sumanasekera, C., Lester, R. L., & Dickson, R. C. (2005) · Biochemical Society Transactions · doi:10.1042/bst0331170 · Cited by 37

Neobiosynthesis of Glycosphingolipids by Plasma Membrane-associated Glycosyltransferases*

Crespo, P. M., Demichelis, V. T., & Daniotti, J. L. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.123422 · Cited by 37

Sphingolipids in Macroautophagy

Lavieu, G., Scarlatti, F., Sala, G., Carpentier, S., Levade, T., Ghidoni, R., Botti, J., & Codogno, P. (2008) · Methods in molecular biology · doi:10.1007/978-1-59745-157-4_11 · Cited by 36

Sulfated Glycosphingolipid as Mediator of Phagocytosis: SM4s Enhances Apoptotic Cell Clearance and Modulates Macrophage Activity

Popović, Z. V., Sandhoff, R., Sijmonsma, T., Kaden, S., Jennemann, R., Kiss, É., Tone, E., Autschbach, F., Platt, N., Malle, E., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.10.6770 · Cited by 36

On the presence of C2-ceramide in mammalian tissues: possible relationship to etherphospholipids and phosphorylation by ceramide kinase

Overloop, H. V., Denizot, Y., Baes, M. I., & Veldhoven, P. P. V. (2007) · Biological Chemistry · doi:10.1515/bc.2007.035 · Cited by 36

Characterization and developmental expression of a novel sulfotransferase for the biosynthesis of sulfoglucuronyl glycolipids in the nervous system.

Chou, D. K. H., & Jungalwala, F. B. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54154-5 · Cited by 35

Regulation of Lactosylceramide Synthase (Glucosylceramide β1→4 Galactosyltransferase); Implication as A Drug Target

Chatterjee, S. B., Kolmakova, A., & Rajesh, M. (2008) · Current Drug Targets · doi:10.2174/138945008783954952 · Cited by 34

Transcript profiling and lipidomic analysis of ceramide subspecies in mouse embryonic stem cells and embryoid bodies

Park, H. J., Haynes, C. A., Nairn, A. V., Kulik, M. J., Dalton, S., Moremen, K. W., & Merrill, A. H. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m000984 · Cited by 34

Molecular Characterization of Membrane-Associated Soluble Serine Palmitoyltransferases from Sphingobacterium multivorum and Bdellovibrio stolpii

Ikushiro, H., Islam, M. M., Tojo, H., et al. (2007) · Journal of Bacteriology · doi:10.1128/jb.00194-07 · Cited by 34

Convenient Structural Analysis of Glycosphingolipids Using MALDI-QIT-TOF Mass Spectrometry with Increased Laser Power and Cooling Gas Flow

Suzuki, Y., Suzuki, M., Ito, E., Goto‐Inoue, N., Miseki, K., Iida, J., Yamazaki, Y., Yamada, M., & Suzuki, A. (2006) · The Journal of Biochemistry · doi:10.1093/jb/mvj090 · Cited by 33

Factors to consider in using [U-C]palmitate for analysis of sphingolipid biosynthesis by tandem mass spectrometry

Haynes, C. A., Allegood, J. C., Wang, E. W., Kelly, S. L., Sullards, M. C., & Merrill, J. A. H. (2011) · Journal of Lipid Research · doi:10.1194/jlr.d015586 · Cited by 33

Further characterization of Δ8-sphingolipid desaturases from higher plants

Sperling, P., Blume, A., Zähringer, U., & Heinz, E. (2000) · Biochemical Society Transactions · doi:10.1042/0300-5127:0280638 · Cited by 32

Calorimetric and x-ray diffraction studies of rye glucocerebroside mesomorphism

Lynch, D. V., Caffrey, M., Hogan, J., et al. (1992) · Biophysical Journal · doi:10.1016/s0006-3495(92)81937-9 · Cited by 31

Fungal Metabolite Sulfamisterin Suppresses Sphingolipid Synthesis through Inhibition of Serine Palmitoyltransferase

Yamaji‐Hasegawa, A., Takahashi, A., TETSUKA, Y., et al. (2004) · Biochemistry · doi:10.1021/bi048605l · Cited by 30

Analogs of the dihydroceramide desaturase inhibitor GT11 modified at the amide function: synthesis and biological activities

Bedia, C., Triola, G., Casas, J., Llebaria, A., & Fabriàs, G. (2005) · Organic & Biomolecular Chemistry · doi:10.1039/b510198k · Cited by 29

A turn in the road: How studies on the pharmacology of glucosylceramide synthase inhibitors led to the identification of a lysosomal phospholipase A2 with ceramide transacylase activity

Shayman, J. A., Abe, A., & Hiraoka, M. (2003) · Glycoconjugate Journal · doi:10.1023/b:glyc.0000016739.32089.55 · Cited by 28

Ganglioside-exposed dendritic cells inhibit T-cell effector function by promoting regulatory cell activity

Jales, A., Falahati, R., Mari, E. R., et al. (2010) · Immunology · doi:10.1111/j.1365-2567.2010.03348.x · Cited by 27

Isolation and mass spectrometry characterization of molecular species of lactosylceramides using liquid chromatography-electrospray ion trap mass spectrometry

Kaga, N., Kazuno, S., Taka, H., Iwabuchi, K., & Murayama, K. (2004) · Analytical Biochemistry · doi:10.1016/j.ab.2004.11.003 · Cited by 27

Identification of an essential sequence for dihydroceramide C‐4 hydroxylase activity of mouse DES2

Omae, F., Miyazaki, M., Enomoto, A., & Suzuki, A. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.08.060 · Cited by 26

Multiple phenotypic changes in mice after knockout of the B3gnt5gene, encoding Lc3 synthase—a key enzyme in lacto-neolacto ganglioside synthesis

Kuan, C., Chang, J., Månsson, J., Li, J., Pegram, C. N., Fredman, P., McLendon, R. E., & Bigner, D. D. (2010) · BMC Developmental Biology · doi:10.1186/1471-213x-10-114 · Cited by 26

A method for visualization of “omic” datasets for sphingolipid metabolism to predict potentially interesting differences

Momin, A. A., Park, H. J., Portz, B. J., Haynes, C. A., Shaner, R. L., Kelly, S. L., Jordan, I. K., & Merrill, J. A. H. (2011) · Journal of Lipid Research · doi:10.1194/jlr.m010454 · Cited by 26

Sphingolipid bases. A revisitation of the O-methyl derivatives of sphingosine. Isolation and characterization of diacetate derivatives, with revised 13C nuclear magnetic resonance assignments for D-erythro-sphingosine.

Kisić, A., Tsuda, M., Kulmacz, R. J., Wilson, W. K., & Schroepfer, G. J. (1995) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)40063-x · Cited by 25

Coordination of the dynamics of yeast sphingolipid metabolism during the diauxic shift

Alvarez‐Vasquez, F., Sims, K. J., Voit, E. O., et al. (2007) · Theoretical Biology and Medical Modelling · doi:10.1186/1742-4682-4-42 · Cited by 24

Trans-activity of Plasma Membrane-associated Ganglioside Sialyltransferase in Mammalian Cells

Vilcaes, A. A., Demichelis, V. T., & Daniotti, J. L. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.257196 · Cited by 22

Structural and compositional difference in the neutral glycolipids between epithelial and non-epithelial tissue of the mouse small intestine

Umesaki, Y., Takamizawa, K., & Ohara, M. (1989) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(89)90142-2 · Cited by 21

Systematic analyses of free ceramide species and ceramide species comprising neutral glycosphingolipids by MALDI-TOF MS with high-energy CID

Tanaka, K., Yamada, M., Tamiya‐Koizumi, K., Kannagi, R., Aoyama, T., Hara, A., & Kyogashima, M. (2011) · Glycoconjugate Journal · doi:10.1007/s10719-011-9325-6 · Cited by 20

Splice Variant-Dependent Regulation of β-Cell Sodium-Calcium Exchange by Acyl-Coenzyme As

Hamming, K. S. C., Riedel, M. J., Soliman, D., Matemisz, L. C., Webster, N. J., Searle, G. J., MacDonald, P. E., & Light, P. E. (2008) · Molecular Endocrinology · doi:10.1210/me.2008-0053 · Cited by 20

Drug target identification in sphingolipid metabolism by computational systems biology tools: Metabolic control analysis and metabolic pathway analysis

Özbayraktar, F. B. K., & Ülgen, K. Ö. (2010) · Journal of Biomedical Informatics · doi:10.1016/j.jbi.2010.03.006 · Cited by 18

The role of tumor necrosis factor α and the peroxisome proliferator-activated receptor α in modulating the effects of fumonisin in mouse liver

Voss, K. A., Riley, R. T., Dunn, C. S., & Corton, J. C. (2006) · Toxicology · doi:10.1016/j.tox.2006.02.012 · Cited by 17

Modification of sphingoglycolipids and sulfolipids in kidney cell lines under heat stress: Activation of monohexosylceramide synthesis as a ceramide scavenger

Niimura, Y., Moue, T., Takahashi, N., & Nagai, K. I. (2010) · Glycobiology · doi:10.1093/glycob/cwq018 · Cited by 17

Computational Analysis of Sphingolipid Pathway Systems

Voit, E. O., Alvarez‐Vasquez, F., & Hannun, Y. A. (2010) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-6741-1_19 · Cited by 16

Chemical and Apoptotic Properties of Hydroxy-Ceramides Containing Long-Chain Bases with Unusual Alkyl Chain Lengths

Kyogashima, M., Tadano‐Aritomi, K., Aoyama, T., Yusa, A., Goto, Y., Tamiya‐Koizumi, K., Ito, H., Murate, T., Kannagi, R., & Hara, A. (2008) · The Journal of Biochemistry · doi:10.1093/jb/mvn050 · Cited by 16

Anticancer activity of a ceramide analog containing a disulfide linkage

Bittman, R., Li, Z., Samadder, P., & Arthur, G. (2006) · Cancer Letters · doi:10.1016/j.canlet.2006.10.026 · Cited by 16

Identification of a Novel l-Serine Analog That Suppresses Osteoclastogenesis in Vitro and Bone Turnover in Vivo

Bahtiar, A., Μatsumoto, T., Nakamura, T., Akiyama, M., Yogo, K., Ishida‐Kitagawa, N., Ogawa, T., & Takeya, T. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.058933 · Cited by 15

In Search of a Solution to the Sphinx-Like Riddle of GM1

Ledeen, R. W., & Wu, G. (2010) · Neurochemical Research · doi:10.1007/s11064-010-0286-0 · Cited by 15

Lysophospholipid transacetylase in the regulation of PAF levels in human monocytes and macrophages

Servillo, L., Balestrieri, C., Giovane, A., et al. (2006) · The FASEB Journal · doi:10.1096/fj.05-5059fje · Cited by 14

Differences in the long chain (sphingoid) base composition of sphingomyelin from rats bearing Morris hepatoma 7777

Merrill, A. H., Wang, E., & Wertz, P. W. (1986) · Lipids · doi:10.1007/bf02535642 · Cited by 13

FUMONISIN B1 REDUCES THE DEVELOPMENT OF MULTIPLE ORGAN FAILURE INDUCED BY ZYMOSAN IN MICE

Cuzzocrea, S., Genovese, T., Mazzon, E., Esposito, E., Crisafulli, C., Paola, R. D., Bramanti, P., & Salvemini, D. (2009) · Shock · doi:10.1097/shk.0b013e31817fbd4a · Cited by 13

Drastically Abnormal Gluco- and Galactosylceramide Composition Does Not Affect Ganglioside Metabolism in the Brain of Mice Deficient in Galactosylceramide Synthase

Suzuki, K., Vanier, M. T., Coetzee, T., & Popko, B. (1999) · Neurochemical Research · doi:10.1023/a:1022571410445 · Cited by 12

Patterns of reactivity with anti‐glycolipid antibodies in human primary brain tumors

Li, J., Pearl, D. K., Pfeiffer, S. E., & Yates, A. J. (1994) · Journal of Neuroscience Research · doi:10.1002/jnr.490390205 · Cited by 12

The medium is the message: Glycosphingolipids and their soluble analogues

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Synthesis of a Cyclopropene Analogue of Ceramide, a Potent Inhibitor of Dihydroceramide Desaturase This work was supported by the Dirección General de Enseñanza Superior e Investigación Científica (grant PB97-1171) and the Departament d'Universitats, Recerca i Societat de la Informació, Generalitat de Catalunya (grant 1999-SGR 00187 and a Predoctoral fellowship to G.T.). We thank Dr. J. Casas, Dr. A. Delgado, and Dr. J. Joglar for their help in different aspects of this work.

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