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Bioisosterism: A Rational Approach in Drug Design
Abstract
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBioisosterism: A Rational Approach in Drug DesignGeorge A. Patani and Edmond J. LaVoieView Author Information Department of Pharmaceutical Chemistry, College of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08855-0789 Cite this: Chem. Rev. 1996, 96, 8, 3147–3176Publication Date (Web):December 19, 1996Publication History Received15 May 1996Revised25 July 1996Published online19 December 1996Published inissue 1 January 1996https://pubs.acs.org/doi/10.1021/cr950066qhttps://doi.org/10.1021/cr950066qresearch-articleACS PublicationsCopyright © 1996 American Chemical SocietyRequest reuse permissionsArticle Views22046Altmetric-Citations1027LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Bioactivity,Hydroxyls,Inhibition,Peptides and proteins,Receptors Get e-Alerts
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Cites
The Triumvirate: β-Cell, Muscle, Liver: A Collusion Responsible for NIDDM
DeFronzo, R. A. (1988) · Diabetes · doi:10.2337/diab.37.6.667 · Cited by 2,456
Macdonald, R. L., & Olsen, R. W. (1994) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.17.030194.003033 · Cited by 1,975
Enhanced synthesis of leukotriene B4 by colonic mucosa in inflammatory bowel disease
Sharon, P., & Stenson, W. F. (1984) · Gastroenterology · doi:10.1016/s0016-5085(84)80015-3 · Cited by 738
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From machine learning to deep learning: progress in machine intelligence for rational drug discovery
Zhang, L., Tan, J., Han, D., & Zhu, H. (2017) · Drug Discovery Today · doi:10.1016/j.drudis.2017.08.010 · Cited by 760
Quest for Novel Chemical Entities through Incorporation of Silicon in Drug Scaffolds
Ramesh, R., & Reddy, D. S. (2018) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.7b00718 · Cited by 624
Garcia Fortanet, J., Chen, C. H.-T., Chen, Y.-N. P., Chen, Z., Deng, Z., Firestone, B., Fekkes, P., Fodor, M., Fortin, P. D., Fridrich, C., et al. (2016) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6b00680 · Cited by 298
Development of tau aggregation inhibitors for alzheimer's disease
Bulic, B., Pickhardt, M., Schmidt, B., Mandelkow, E., Waldmann, H., & Mandelkow, E. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200802621 · Cited by 286
Biosynthesis and Chemical Applications of Thioamides
Mahanta, N., Szantai-Kis, D. M., Petersson, E. J., & Mitchell, D. A. (2019) · ACS Chemical Biology · doi:10.1021/acschembio.8b01022 · Cited by 218
Metadata
- Authors
- Patani, G. A., & LaVoie, E. J.
- Venue
- Chemical Reviews
- Publisher
- American Chemical Society (ACS)
- Published
- 1996-01-01
- Volume
- 96
- Issue
- 8
- Pages
- 3147-3176
- ISSN
- 0009-2665 (ISSN-L)
- 1520-6890
- OpenAlex
- W2085313140
- Cited by
- 1,328
- References
- 3
- FWCI
- 0.60
- Type
- journal article
- Language
- en
- Open access
- closed
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