The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Copper Oxide Nanoparticle Mediated DNA Damage in Terrestrial Plant Models
Abstract
Engineered nanoparticles, due to their unique electrical, mechanical, and catalytic properties, are presently found in many commercial products and will be intentionally or inadvertently released at increasing concentrations into the natural environment. Metal- and metal oxide-based nanomaterials have been shown to act as mediators of DNA damage in mammalian cells, organisms, and even in bacteria, but the molecular mechanisms through which this occurs are poorly understood. For the first time, we report that copper oxide nanoparticles induce DNA damage in agricultural and grassland plants. Significant accumulation of oxidatively modified, mutagenic DNA lesions (7,8-dihydro-8-oxoguanine; 2,6-diamino-4-hydroxy-5-formamidopyrimidine; 4,6-diamino-5-formamidopyrimidine) and strong plant growth inhibition were observed for radish (Raphanus sativus), perennial ryegrass (Lolium perenne), and annual ryegrass (Lolium rigidum) under controlled laboratory conditions. Lesion accumulation levels mediated by copper ions and macroscale copper particles were measured in tandem to clarify the mechanisms of DNA damage. To our knowledge, this is the first evidence of multiple DNA lesion formation and accumulation in plants. These findings provide impetus for future investigations on nanoparticle-mediated DNA damage and repair mechanisms in plants.
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Cites
Free Radicals in Biology and Medicine
Halliwell, B., & Gutteridge, J. M. C. (2015) · doi:10.1093/acprof:oso/9780198717478.001.0001 · Cited by 8,990
Size-dependent toxicity of metal oxide particles—A comparison between nano- and micrometer size
Karlsson, H. L., Gustafsson, J., Cronholm, P., & Möller, L. (2009) · Toxicology Letters · doi:10.1016/j.toxlet.2009.03.014 · Cited by 949
Molecular Mechanisms of DNA Damage and Repair: Progress in Plants
Tuteja, N., Singh, M. B., Misra, M. K., Bhalla, P. L., & Tuteja, R. (2001) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/20014091074219 · Cited by 272
Cited by
Zuverza-Mena, N., Martínez-Fernández, D., Du, W., Hernandez-Viezcas, J. A., Bonilla-Bird, N., López-Moreno, M. L., Komárek, M., Peralta-Videa, J. R., & Gardea-Torresdey, J. L. (2017) · Plant Physiology and Biochemistry · doi:10.1016/j.plaphy.2016.05.037 · Cited by 426
Rico, C. M., Hong, J., Morales, M. I., Zhao, L., Barrios, A. C., Zhang, J.-Y., Peralta-Videa, J. R., & Gardea-Torresdey, J. L. (2013) · Environmental Science & Technology · doi:10.1021/es401032m · Cited by 342
Phytotoxic hazards of NiO-nanoparticles in tomato: A study on mechanism of cell death
Faisal, M., Saquib, Q., Alatar, A. A., Al-Khedhairy, A. A., Hegazy, A. K., & Musarrat, J. (2013) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2013.01.063 · Cited by 337
Nanomaterials in plant tissue culture: The disclosed and undisclosed
Kim, D. H., Gopal, J., & Sivanesan, I. (2017) · RSC Advances · doi:10.1039/c7ra07025j · Cited by 273
Metadata
- Authors
- Atha, D. H., Wang, H., Petersen, E. J., Cleveland, D., Holbrook, R. D., Jaruga, P., Dizdaroglu, M., Xing, B., & Nelson, B. C.
- Venue
- Environmental Science & Technology
- Publisher
- American Chemical Society (ACS)
- Published
- 2012-01-20
- Volume
- 46
- Issue
- 3
- Pages
- 1819-1827
- ISSN
- 0013-936X (ISSN-L)
- 1520-5851
- OpenAlex
- W1970200789
- Cited by
- 511
- References
- 3
- FWCI
- 7.44
- Type
- journal article
- Language
- en
- Open access
- closed
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- Atha, D. H., Wang, H., Petersen, E. J., Cleveland, D., Holbrook, R. D., Jaruga, P., Dizdaroglu, M., Xing, B., & Nelson, B. C. (2012). Copper Oxide Nanoparticle Mediated DNA Damage in Terrestrial Plant Models. Environmental Science & Technology. https://doi.org/10.1021/es202660k
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