The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Generation of Reactive Oxygen Species Mediated by Humic-like Substances in Atmospheric Aerosols
Abstract
Particulate matter (PM)-mediated reactive oxygen species (ROS) generation has been implicated in health effects posed by PM. Humic-like substances (HULIS) are an unresolved mixture of water-extracted organic compounds from atmospheric aerosol particles or isolated from fog/cloudwater samples. In this study, we use a cell-free dithiothreitol (DTT) assay to measure ROS production mediated by HULIS. The HULIS samples are isolated from aerosols collected at a rural location and a suburban location in the Pearl River Delta, China. In our experiments, ROS activities by residue metal ions in the HULIS fraction are suppressed by including a strong chelating agent in the DTT assay. Under conditions of DTT consumption not exceeding 90%, the HULIS-catalyzed oxidation of DTT follows the zero-order kinetics with respect to DTT concentration, and the rate of DTT oxidation is proportional to the dose of HULIS. The ROS activity of the aerosol HULIS, on a per unit mass basis is 2% of the ROS activity by a reference quinone compound, 1,4-naphthoquinone and exceeds that of two aquatic fulvic acids. The HULIS fraction in the ambient samples tested exhibits comparable ROS activities to the organic solvent extractable fraction, which would contain compounds such as quinones, a known organic compound class capable of catalyzing generation of ROS in cells. HULIS was found to be the major redox active constituent of the water-extractable organic fraction in PM. It is plausible that HULIS contains reversible redox sites, thereby serving as electron carriers to catalyze the formation of ROS. Our work suggests that HULIS could be an active PM component in generating ROS and further work is warranted to characterize its redox properties.
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Cites
Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage
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Redox activity of airborne particulate matter at different sites in the Los Angeles Basin
Cho, A. K., Sioutas, C., Miguel, A. H., Kumagai, Y., Schmitz, D. A., Singh, M., Eiguren-Fernandez, A., & Froines, J. R. (2005) · Environmental Research · doi:10.1016/j.envres.2005.01.003 · Cited by 770
Atmospheric HULIS: How humic-like are they? A comprehensive and critical review
Graber, E. R., & Rudich, Y. (2006) · Atmospheric Chemistry and Physics · doi:10.5194/acp-6-729-2006 · Cited by 741
Role of Free Radicals in the Toxicity of Airborne Fine Particulate Matter
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Health Effects of Organic Aerosols
Mauderly, J. L., & Chow, J. C. (2008) · Inhalation Toxicology · doi:10.1080/08958370701866008 · Cited by 493
Squadrito, G. L., Cueto, R., Dellinger, B., & Pryor, W. A. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00703-1 · Cited by 481
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Reactive oxygen species in pulmonary inflammation by ambient particulates
Tao, F., Gonzalez-Flecha, B., & Kobzik, L. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00280-6 · Cited by 392
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Characterization and Quantification of Reversible Redox Sites in Humic Substances
Ratasuk, N., & Nanny, M. A. (2007) · Environmental Science & Technology · doi:10.1021/es071389u · Cited by 327
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Fang, T., Guo, H., Zeng, L., Verma, V., Nenes, A., & Weber, R. J. (2017) · Environmental Science & Technology · doi:10.1021/acs.est.6b06151 · Cited by 584
Charrier, J. G., & Anastasio, C. (2012) · Atmospheric Chemistry and Physics · doi:10.5194/acp-12-9321-2012 · Cited by 473
Fang, T., Verma, V., Bates, J. T., Abrams, J., Klein, M., Strickland, M. J., Sarnat, S. E., Chang, H. H., Mulholland, J. A., Tolbert, P. E., et al. (2016) · Atmospheric Chemistry and Physics · doi:10.5194/acp-16-3865-2016 · Cited by 373
Verma, V., Fang, T., Xu, L., Peltier, R. E., Russell, A. G., Ng, N. L., & Weber, R. J. (2015) · Environmental Science & Technology · doi:10.1021/es505577w · Cited by 366
Metadata
- Authors
- Lin, P., & Yu, J. Z.
- Venue
- Environmental Science & Technology
- Publisher
- American Chemical Society (ACS)
- Published
- 2011-11-15
- Volume
- 45
- Issue
- 24
- Pages
- 10362-10368
- ISSN
- 0013-936X (ISSN-L)
- 1520-5851
- OpenAlex
- W1968518857
- Cited by
- 273
- References
- 40
- FWCI
- 4.76
- Type
- journal article
- Language
- en
- Open access
- closed
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