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Regiospecifically oxygen-18 labeled 1,2,4-trioxane: a simple chemical model system to probe the mechanism(s) for the antimalarial activity of artemisinin (qinghaosu).
Abstract
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRegiospecifically oxygen-18 labeled 1,2,4-trioxane: a simple chemical model system to probe the mechanism(s) for the antimalarial activity of artemisinin (qinghaosu).Gary H. Posner and Chang Ho OhCite this: J. Am. Chem. Soc. 1992, 114, 21, 8328–8329Publication Date (Print):October 1, 1992Publication History Published online1 May 2002Published inissue 1 October 1992https://pubs.acs.org/doi/10.1021/ja00047a076https://doi.org/10.1021/ja00047a076research-articleACS PublicationsRequest reuse permissionsArticle Views810Altmetric-Citations165LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
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Citations
Cited by
A Medicinal Chemistry Perspective on Artemisinin and Related Endoperoxides
O'Neill, P. M., & Posner, G. H. (2004) · Journal of Medicinal Chemistry · doi:10.1021/jm030571c · Cited by 538
Self-citationIron-dependent free radical generation from the antimalarial agent artemisinin (qinghaosu)
Meshnick, S. R., Yang, Y. Z., Lima, V, Kuypers, F., Kamchonwongpaisan, S., & Yuthavong, Y. (1993) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.37.5.1108 · Cited by 327
Artemisinin and the antimalarial endoperoxides: from herbal remedy to targeted chemotherapy
Meshnick, S. R., Taylor, T. E., & Kamchonwongpaisan, S. (1996) · Microbiological Reviews · doi:10.1128/mmbr.60.2.301-315.1996 · Cited by 710
“The endoperoxide bridge is cleaved first (131); this is followed by intramolecular electronic rearrangements which produce carbon-centered radicals (55, 131, 134, 136).”
BackgroundHaynes, R. K., Chan, W. C., Lung, C., Uhlemann, A., Eckstein, U., Taramelli, D., Parapini, S., Monti, D., & Krishna, S. (2007) · ChemMedChem · doi:10.1002/cmdc.200700108 · Cited by 123
Recent advances in antimalarial drug development
Vangapandu, S., Jain, M., Kaur, K., Patil, P., Patel, S. R., & Jain, R. (2007) · Medicinal Research Reviews · doi:10.1002/med.20062 · Cited by 108
Metadata
- Authors
- Posner, G. H., & Oh, C. H.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 1992-10
- Volume
- 114
- Issue
- 21
- Pages
- 8328-8329
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2070457129
- Cited by
- 193
- References
- 0
- FWCI
- 9.66
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Regiospecifically oxygen-18 labeled 1,2,4-trioxane: a simple chemical model system to probe the mechanism(s) for the antimalarial activity of artemisinin (qinghaosu). https://app.cochat.ai/papers/10.1021/ja00047a076
- The paper
- Posner, G. H., & Oh, C. H. (1992). Regiospecifically oxygen-18 labeled 1,2,4-trioxane: a simple chemical model system to probe the mechanism(s) for the antimalarial activity of artemisinin (qinghaosu). Journal of the American Chemical Society. https://doi.org/10.1021/ja00047a076
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