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Deoxyribozyme-Based Logic Gates
Abstract
We report herein a set of deoxyribozyme-based logic gates capable of generating any Boolean function. We construct basic NOT and AND gates, followed by the more complex XOR gate. These gates were constructed through a modular design that combines molecular beacon stem-loops with hammerhead-type deoxyribozymes. Importantly, as the gates have oligonucleotides as both inputs and output, they open the possibility of communication between various computation elements in solution. The operation of these gates is conveniently connected to a fluorescent readout.
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Citations
Cited by
Dynamic DNA nanotechnology using strand-displacement reactions
Zhang, D. Y., & Seelig, G. (2011) · Nature Chemistry · doi:10.1038/nchem.957 · Cited by 1,785
Enzyme-Free Nucleic Acid Logic Circuits
Seelig, G., Soloveichik, D., Zhang, D. Y., & Winfree, E. (2006) · Science · doi:10.1126/science.1132493 · Cited by 1,540
Materials learning from life: concepts for active, adaptive and autonomous molecular systems
Merindol, R., & Walther, A. (2017) · Chemical Society Reviews · doi:10.1039/c6cs00738d · Cited by 533
Directed Evolution of Nucleic Acid Enzymes
Joyce, G. F. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.073717 · Cited by 515
Metadata
- Authors
- Stojanovic, M. N., Mitchell, T. E., & Stefanovic, D.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2002-03-14
- Volume
- 124
- Issue
- 14
- Pages
- 3555-3561
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2047206115
- Cited by
- 485
- References
- 0
- FWCI
- 4.54
- Type
- journal article
- Language
- en
- Open access
- closed
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