The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Micelle-Induced Curvature in a Water-Insoluble HIV-1 Env Peptide Revealed by NMR Dipolar Coupling Measurement in Stretched Polyacrylamide Gel
Abstract
The structure of a water-insoluble fragment encompassing residues 282-304 of the HIV envelope protein gp41 is studied when solubilized by dihexanoyl phosphatidylcholine (DHPC) and by small bicelles, consisting of a 4:1 molar ratio of DHPC and dimyristoyl phosphatidylcholine (DMPC). Weak alignment with the magnetic field was accomplished in a stretched polyacrylamide gel, permitting measurement of one-bond (1)H-(15)N, (13)Ca-(13)C', and (13)C'-(15)N dipolar couplings, which formed the basis for determining the peptide structure. In both detergent systems, the peptide adopts an alpha-helical conformation from residue 4 through 18. In the presence of the DHPC micelles the helix is strongly curved towards the hydrophobic surface, whereas in the presence of bicelles a much weaker curvature in the opposite direction is observed.
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Citations
Cites
Protein backbone angle restraints from searching a database for chemical shift and sequence homology
Cornilescu, G., Delaglio, F., & Bax, A. (1999) · Journal of Biomolecular NMR · doi:10.1023/a:1008392405740 · Cited by 2,957
Cited by
Structure Determination of Membrane Proteins by NMR Spectroscopy
Opella, S. J., & Marassi, F. M. (2004) · Chemical Reviews · doi:10.1021/cr0304121 · Cited by 425
Residual Dipolar Couplings in Structure Determination of Biomolecules
Prestegard, J. H., Bougault, C. M., & Kishore, A. I. (2004) · Chemical Reviews · doi:10.1021/cr030419i · Cited by 416
The Magic of Bicelles Lights Up Membrane Protein Structure
Dürr, U. H. N., Gildenberg, M., & Ramamoorthy, A. (2012) · Chemical Reviews · doi:10.1021/cr300061w · Cited by 362
The structure of phospholamban pentamer reveals a channel-like architecture in membranes
Oxenoid, K., & Chou, J. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504920102 · Cited by 320
Self-citationSun, Z.-Y. J., Oh, K. J., Kim, M., Yu, J., Brusic, V., Song, L., Qiao, Z., Wang, J.-H., Wagner, G., & Reinherz, E. L. (2008) · Immunity · doi:10.1016/j.immuni.2007.11.018 · Cited by 279
Metadata
- Authors
- Chou, J. J., Kaufman, J. D., Stahl, S. J., Wingfield, P. T., & Bax, A.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2002-02-26
- Volume
- 124
- Issue
- 11
- Pages
- 2450-2451
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2072239334
- Cited by
- 184
- References
- 1
- FWCI
- 7.76
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
