The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Mimicry of Host-Defense Peptides by Unnatural Oligomers: Antimicrobial β-Peptides
Abstract
We have designed beta-amino acid oligomers that are helical, cationic, and amphiphilic with the intention of mimicking the biological activity of amphiphilic, cationic alpha-helical antimicrobial peptides found in nature (e.g., magainins). We have previously identified a 17-residue beta-peptide (called beta-17) with antibiotic activity similar to that of a magainin derivative against four bacterial species, including two clinical isolates that are resistant to common antibiotics. This beta-peptide displays very low hemolytic activity against human red blood cells, which indicates selectivity for bacterial cells over mammalian cells. Here we examine some of the factors important for activity in this class of beta-peptides. An amphiphilic helix is necessary, because a nonamphiphilic isomer proved to be inactive. The ratio of cationic to hydrophobic residues is also important. Active beta-peptides induce the leakage of beta-galactosidase from treated Bacillus subtilis cells, as do alpha-helical antibiotic peptides, and this similarity suggests that the beta-peptide mode of action involves disruption of microbial membranes. This class of beta-peptides is not degraded by proteases, which bodes well for biological applications.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Yanisch-Perron, C., Vieira, J., & Messing, J. (1985) · Gene · doi:10.1016/0378-1119(85)90120-9 · Cited by 15,041
Antimicrobial peptides of multicellular organisms
Zasloff, M. (2002) · Nature · doi:10.1038/415389a · Cited by 8,457
Gellman, S. H. (1998) · Accounts of Chemical Research · doi:10.1021/ar960298r · Cited by 2,506
Self-citationZasloff, M. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.15.5449 · Cited by 2,305
β-Peptides: From Structure to Function
Cheng, R. P., Gellman, S. H., & DeGrado, W. F. (2001) · Chemical Reviews · doi:10.1021/cr000045i · Cited by 1,862
Self-citationA spectrophotometric determination of trypsin and chymotrypsin
Schwert, G. W., & Takenaka, Y. (1955) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(55)90280-8 · Cited by 1,545
Sequence and specificity of two antibacterial proteins involved in insect immunity
Steiner, H., Hultmark, D., Engström, Å., Bennich, H., & Boman, H. G. (1981) · Nature · doi:10.1038/292246a0 · Cited by 1,427
Bee and Wasp Venoms: The biochemistry and pharmacology of their peptides and enzymes are reviewed.
Habermann, E. (1972) · Science · doi:10.1126/science.177.4046.314 · Cited by 1,324
Membrane Pores Induced by Magainin
Ludtke, S. J., He, K., Heller, W. T., Harroun, T. A., Yang, L., & Huang, H. W. (1996) · Biochemistry · doi:10.1021/bi9620621 · Cited by 802
Non-haemolytic β-amino-acid oligomers
Porter, E. A., Wang, X., Lee, H.-S., Weisblum, B., & Gellman, S. H. (2000) · Nature · doi:10.1038/35007145 · Cited by 671
Self-citation
Cited by
Antibacterial peptides: basic facts and emerging concepts
Boman, H. G. (2003) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.2003.01228.x · Cited by 1,158
Seebach, D., Beck, A. K., & Bierbaum, D. J. (2004) · Chemistry & Biodiversity · doi:10.1002/cbdv.200490087 · Cited by 932
Peptoids that mimic the structure, function, and mechanism of helical antimicrobial peptides
Chongsiriwatana, N. P., Patch, J. A., Czyzewski, A. M., Dohm, M. T., Ivankin, A., Gidalevitz, D., Zuckermann, R. N., & Barron, A. E. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708254105 · Cited by 657
Combating Multidrug‐Resistant Bacteria: Current Strategies for the Discovery of Novel Antibacterials
O'Connell, K. M. G., Hodgkinson, J. T., Sore, H. F., Welch, M., Salmond, G. P. C., & Spring, D. R. (2013) · Angewandte Chemie International Edition · doi:10.1002/anie.201209979 · Cited by 435
Helical Peptoid Mimics of Magainin-2 Amide
Patch, J. A., & Barron, A. E. (2003) · Journal of the American Chemical Society · doi:10.1021/ja037320d · Cited by 375
Vasudev, P. G., Chatterjee, S., Shamala, N., & Balaram, P. (2011) · Chemical Reviews · doi:10.1021/cr100100x · Cited by 329
Park, S.-C., Park, Y., & Hahm, K.-S. (2011) · International Journal of Molecular Sciences · doi:10.3390/ijms12095971 · Cited by 327
Biomimetic antimicrobial polymers: recent advances in molecular design
Ergene, C., Yasuhara, K., & Palermo, E. F. (2018) · Polymer Chemistry · doi:10.1039/c8py00012c · Cited by 312
Spontaneous transmembrane pore formation by short-chain synthetic peptide
(2021) · doi:10.1016/j.bpj.2021.08.033 · Cited by 9
Metadata
- Authors
- Porter, E. A., Weisblum, B., & Gellman, S. H.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2002-06-01
- Volume
- 124
- Issue
- 25
- Pages
- 7324-7330
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W1975313075
- Cited by
- 379
- References
- 38
- FWCI
- 14.96
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
