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A Novel Strategy for Encapsulation and Release of Proteins: Hydrogels and Microgels with Acid-Labile Acetal Cross-Linkers
Abstract
A new acid-labile acetal cross-linker was synthesized and used to prepare protein-loaded hydrogels and microgels. This cross-linker undergoes an acid-catalyzed degradation with a half-life of 5.5 min at pH 5.0 and 24 h at pH 7.4. Protein-loaded hydrogels were synthesized with this cross-linker, and their release profiles were measured as a function of pH. Hydrogels made with the acetal cross-linker release their contents in a pH-dependent manner. The acetal cross-linker was also used to synthesize microgels with sizes between 1 and 10 mum, a range suitable for phagocytosis. The unique acid sensitivity of the acetal cross-linker should make it a useful synthetic intermediate in the design of acid-sensitive drug or gene delivery systems.
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Metadata
- Authors
- Murthy, N., Thng, Y. X., Schuck, S., Xu, M. C., & Fréchet, J. M. J.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2002-10-01
- Volume
- 124
- Issue
- 42
- Pages
- 12398-12399
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2024351675
- Cited by
- 407
- References
- 0
- FWCI
- 5.26
- Type
- journal article
- Language
- en
- Open access
- closed
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- Murthy, N., Thng, Y. X., Schuck, S., Xu, M. C., & Fréchet, J. M. J. (2002). A Novel Strategy for Encapsulation and Release of Proteins: Hydrogels and Microgels with Acid-Labile Acetal Cross-Linkers. Journal of the American Chemical Society. https://doi.org/10.1021/ja026925r
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