The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Designing Macromolecules for Therapeutic Applications: Polyester DendrimerPoly(ethylene oxide) “Bow-Tie” Hybrids with Tunable Molecular Weight and Architecture
Abstract
The design and preparation of new polyester dendrimer, poly(ethylene oxide) hybrid systems for drug delivery and related therapeutic applications, are described. These systems consist of two covalently attached polyester dendrons, where one dendron provides multiple functional handles for the attachment of therapeutically active moieties, while the other is used for attachment of solubilizing poly(ethylene oxide) chains. By varying the generation of the dendrons and the mass of the poly(ethylene oxide) chains, the molecular weight, architecture, and drug loading can be readily controlled. The "bow-tie" shaped dendritic scaffold was synthesized using both convergent and divergent methods, with orthogonal protecting groups on the periphery of the two dendrons. Poly(ethylene oxide) was then attached to the periphery of one dendron using an efficient coupling procedure. A small library of eight carriers with molecular weights ranging from about 20 kDa to 160 kDa were prepared and characterized by various techniques, confirming their well-defined structures.
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Citations
Cites
Polyester Dendritic Systems for Drug Delivery Applications: In Vitro and In Vivo Evaluation
Padilla De Jesús, O. L., Ihre, H. R., Gagne, L., Fréchet, J. M. J., & Szoka, F. C. (2002) · Bioconjugate Chemistry · doi:10.1021/bc010103m · Cited by 507
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Cited by
Cancer nanotechnology: opportunities and challenges
Ferrari, M. (2005) · Nature Reviews Cancer · doi:10.1038/nrc1566 · Cited by 4,558
Dendrimers in biomedical applications—reflections on the field
SVENSON, S., & TOMALIA, D. (2005) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2005.09.018 · Cited by 1,919
Dendrimers in Oncology: An Expanding Horizon
Tekade, R. K., Kumar, P. V., & Jain, N. K. (2009) · Chemical Reviews · doi:10.1021/cr068212n · Cited by 466
Simplifying the synthesis of dendrimers: accelerated approaches
Walter, M. V., & Malkoch, M. (2012) · Chemical Society Reviews · doi:10.1039/c2cs35062a · Cited by 301
Dendrimeric micelles for controlled drug release and targeted delivery
Ambade, A. V., Savariar, E. N., & Thayumanavan, S. (2005) · Molecular Pharmaceutics · doi:10.1021/mp050020d · Cited by 245
Metadata
- Authors
- Gillies, E. R., & Fréchet, J. M. J.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2002-11-01
- Volume
- 124
- Issue
- 47
- Pages
- 14137-14146
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2014354647
- Cited by
- 328
- References
- 1
- FWCI
- 17.09
- Type
- journal article
- Language
- en
- Open access
- closed
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