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Modular Aptameric Sensors
Abstract
We report the first examples of modular aptameric sensors, which transduce recognition events into fluorescence changes through allosteric regulation of noncovalent interactions with a fluorophore. These sensors consist of: (a) a reporting domain, which signals the binding event of an analyte through binding to a fluorophore; (b) a recognition domain, which binds the analyte; and (c) a communication module, which serves as a conduit between recognition and signaling domains. We tested recognition regions specific for ATP, FMN, and theophylline in combinations with malachite green binding aptamer as a signaling domain. In each case, we were able to obtain a functional sensor capable of responding to an increase in analyte concentration with an increase in fluorescence. Similar constructs that consist only of natural RNA could be expressed in cells and used as sensors for intracellular imaging.
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Cited by
Applications of Aptamers as Sensors
Cho, E. J., Lee, J.-W., & Ellington, A. D. (2009) · Annual Review of Analytical Chemistry · doi:10.1146/annurev.anchem.1.031207.112851 · Cited by 788
In Vitro Selection of Structure‐Switching Signaling Aptamers
Nutiu, R., & Li, Y. (2005) · Angewandte Chemie International Edition · doi:10.1002/anie.200461848 · Cited by 455
Optical aptasensors for quantitative detection of small biomolecules: A review
Feng, C., Dai, S., & Wang, L. (2014) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2014.03.014 · Cited by 300
Size, constant sequences, and optimal selection
LEGIEWICZ, M., LOZUPONE, C., KNIGHT, R., & YARUS, M. (2005) · RNA · doi:10.1261/rna.2161305 · Cited by 69
Emerging affinity-based techniques in proteomics
Xie, S., Moya, C., Bilgin, B., Jayaraman, A., & Walton, S. P. (2009) · Expert Review of Proteomics · doi:10.1586/epr.09.74 · Cited by 38
Metadata
- Authors
- Stojanovic, M. N., & Kolpashchikov, D. M.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2004-07-08
- Volume
- 126
- Issue
- 30
- Pages
- 9266-9270
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2001266050
- Cited by
- 322
- References
- 0
- FWCI
- 6.34
- Type
- journal article
- Language
- en
- Open access
- closed
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