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Cited by 324

The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.

Impact of Protein Denaturants and Stabilizers on Water Structure

Batchelor, Joseph D., Olteanu, Alina, Tripathy, Ashutosh, Pielak, Gary J.·2004·Journal of the American Chemical Society
DOI 10.1021/ja039335h
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Abstract

It is of great interest to determine how solutes such as urea, sugars, guanidinium salts, and trimethylamine N-oxide affect the stability, solubility, and solvation of globular proteins. A key hypothesis in this field states that solutes affect protein stability indirectly by making or breaking water structure. We used a new technique, pressure perturbation calorimetry, to measure the temperature dependence of a solute's partial compressibility. Using fundamental thermodynamic relations, we converted these data to the pressure dependence of the partial heat capacity to examine the impact of protein stabilizing and denaturing solutes on water structure by applying the classic two-state mixture model for water. Contrary to widely held expectations, we found no correlation between a solute's impact on water structure and its effect on protein stability. Our results indicate that efforts to explain solute effects should focus on other hypotheses, including those based on preferential interaction and excluded volume.

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Metadata

Authors
Batchelor, J. D., Olteanu, A., Tripathy, A., & Pielak, G. J.
Venue
Journal of the American Chemical Society
Publisher
American Chemical Society (ACS)
Published
2004-01-23
Volume
126
Issue
7
Pages
1958-1961
ISSN
  • 0002-7863 (ISSN-L)
  • 1520-5126
DOI
10.1021/ja039335h
OpenAlex
W1978188750
Cited by
324
References
16
FWCI
21.13
Type
journal article
Language
en
Open access
closed

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.