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Discovery of Potent Cell Migration Inhibitors through Total Synthesis: Lessons from Structure−Activity Studies of (+)-Migrastatin
Abstract
Synthesis of highly active migrastatin-based tumor migration cell inhibitors has been accomplished. Our flexible and concise total synthesis of migrastatin has allowed us to explore otherwise inaccessible migrastatin-derived structural motifs. This effort has resulted in the discovery of analogues with tumor cell migration inhibitory activity 3 orders of magnitude higher than that of the natural product.
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Citations
Cited by
Impact of Natural Products on Developing New Anti-Cancer Agents
Cragg, G. M., Grothaus, P. G., & Newman, D. J. (2009) · Chemical Reviews · doi:10.1021/cr900019j · Cited by 1,302
The Renaissance of Natural Products as Drug Candidates
Paterson, I., & Anderson, E. A. (2005) · Science · doi:10.1126/science.1116364 · Cited by 559
Modulators of Protein–Protein Interactions
Milroy, L.-G., Grossmann, T. N., Hennig, S., Brunsveld, L., & Ottmann, C. (2014) · Chemical Reviews · doi:10.1021/cr400698c · Cited by 497
Chemo- and site-selective derivatizations of natural products enabling biological studies
Robles, O., & Romo, D. (2014) · Nat. Prod. Rep. · doi:10.1039/c3np70087a · Cited by 154
Metadata
- Authors
- Njardarson, J. T., Gaul, C., Shan, D., Huang, X.-Y., & Danishefsky, S. J.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2004-01-07
- Volume
- 126
- Issue
- 4
- Pages
- 1038-1040
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2028677895
- Cited by
- 166
- References
- 0
- FWCI
- 3.50
- Type
- journal article
- Language
- en
- Open access
- closed
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- Njardarson, J. T., Gaul, C., Shan, D., Huang, X.-Y., & Danishefsky, S. J. (2004). Discovery of Potent Cell Migration Inhibitors through Total Synthesis: Lessons from Structure−Activity Studies of (+)-Migrastatin. Journal of the American Chemical Society. https://doi.org/10.1021/ja039714a
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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