A Simple Glycol Nucleic Acid
Abstract
A glycol nucleic acid (GNA) with an acyclic propylene glycol phosphodiester backbone forms stable antiparallel duplexes following the Watson-Crick base pairing rules.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Complementary oligomers of GNA form antiparallel double helices with surprisingly high duplex stabilities.
“Complementary oligomers of GNA form antiparallel, double helices with surprisingly high duplex stabilities.”
From Protocells and RNA Self-Replication (2018) · cites this paper as Zhang et al. 2005
Cited by
Sorted by citations
Robertson, M. P., & Joyce, G. F. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a003608 · Cited by 556 · see citing works
Protocells and RNA Self-Replication
Joyce, G. F., & Szostak, J. W. (2018) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a034801 · Cited by 308 · see citing works
The Implausibility of Metabolic Cycles on the Prebiotic Earth
Orgel, L. E. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060018 · Cited by 271 · see citing works
Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates
Brown, K. M., Nair, J. K., Janas, M. M., Anglero-Rodriguez, Y. I., Dang, L. T. H., Peng, H., Theile, C. S., Castellanos-Rizaldos, E., Brown, C., Foster, D., et al. (2022) · Nature Biotechnology · doi:10.1038/s41587-022-01334-x · Cited by 258 · see citing works
The origin of the biologically coded amino acids
Cleaves II, H. J. (2010) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2009.12.014 · Cited by 108 · see citing works
Fast and accurate nonenzymatic copying of an RNA-like synthetic genetic polymer
Zhang, S., Blain, J. C., Zielinska, D., Gryaznov, S. M., & Szostak, J. W. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1312329110 · Cited by 80 · see citing works
Yang, Y.-W., Zhang, S., McCullum, E. O., & Chaput, J. C. (2007) · Journal of Molecular Evolution · doi:10.1007/s00239-007-9017-9 · Cited by 68 · see citing works
Bit by bit: The Darwinian basis of life
Joyce, G. F. (2012) · PLoS Biology · doi:10.1371/journal.pbio.1001323 · Cited by 45 · see citing works
Adenosine residues in the template do not block spontaneous replication steps of RNA
Vogel, S. R., & Richert, C. (2007) · Chemical Communications · doi:10.1039/b702768k · Cited by 28 · see citing works
- Authors
- Zhang, L., Peritz, A., & Meggers, E.
- Affiliations
- University of Pennsylvania (US)
- ORCID
- Meggers, Eric
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2005-03-01
- Volume
- 127
- Issue
- 12
- Pages
- 4174-4175
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2042037994
- Cited by
- 308
- References
- 0
- Citations by year
- 2026: 13 · 2025: 9 · 2024: 10 · 2023: 17 · 2022: 17 · 2021: 13 · 2020: 19 · 2019: 18 · 2018: 13 · 2017: 12 · 2016: 18 · 2015: 14 · 2014: 15 · 2013: 12 · 2012: 13
- FWCI
- 5.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the American Chemical Society (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Materials Research Science and Engineering Center, Harvard University
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Keywords
- Watson-Crick base pairing, nucleic acid analogs, nucleic acid stability
- MeSH terms
- Circular Dichroism, DNA, Epoxy Compounds, Glycols, Nucleic Acids, Nucleotides, Oligonucleotides, RNA, Stereoisomerism, Propanols
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
