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Intramolecular C−N Bond Addition of Amides to Alkynes Using Platinum Catalyst

Shimada, Tomohiro, Nakamura, Itaru, Yamamoto, Yoshinori·2004·Journal of the American Chemical Society

Abstract

The intramolecular aminoacylation of alkynes using ortho-alkynylacetanilides proceeds in very high yields in the presence of PtCl2 catalyst. This reaction provides not only a useful procedure for synthesizing 2,3-disubstituted indoles at once from ortho-alkynylaniline derivatives, but also an interesting mechanistic aspect; the intramolecular C-N bond addition of amides to alkynes takes place readily in the presence of Pt(II) catalyst.

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Metadata

Authors
Shimada, T., Nakamura, I., & Yamamoto, Y.
Venue
Journal of the American Chemical Society
Published
2004-08-06
Volume
126
Issue
34
Pages
10546-10547
ISSN
  • 0002-7863 (ISSN-L)
  • 1520-5126
OpenAlex
W2057509572
Cited by
233
References
0
FWCI
6.14
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Intramolecular C−N Bond Addition of Amides to Alkynes Using Platinum Catalyst. https://app.cochat.ai/papers/10.1021/ja047542r
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Shimada, T., Nakamura, I., & Yamamoto, Y. (2004). Intramolecular C−N Bond Addition of Amides to Alkynes Using Platinum Catalyst. Journal of the American Chemical Society. https://doi.org/10.1021/ja047542r

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