The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Detection of Bacteria with Carbohydrate-Functionalized Fluorescent Polymers
Abstract
Many pathogens that infect humans use cell surface carbohydrates as receptors to facilitate cell-cell adhesion. The hallmark of these interactions is their multivalency, or the simultaneous occurrence of multiple interactions. We have used a carbohydrate-functionalized fluorescent polymer, which displays many carbohydrate ligands on a single polymer chain, to allow for multivalent detection of pathogens. Incubation of a mannose-functionalized polymer with Escherichia coli yields brightly fluorescent aggregates of bacteria. These results show that carbohydrate-functionalized fluorescent polymers are a versatile detection method for bacteria. Future design of detectors for other pathogens only requires information on the carbohydrates bound by the organisms, which has been exhaustively reported in the literature.
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Cites
Colorimetric Method for Determination of Sugars and Related Substances
DuBois, M., Gilles, K. A., Hamilton, J. K., Rebers, P. A., & Smith, F. (1956) · Analytical Chemistry · doi:10.1021/ac60111a017 · Cited by 52,269
Cited by
Ladmiral, V., Mantovani, G., Clarkson, G. J., Cauet, S., Irwin, J. L., & Haddleton, D. M. (2006) · Journal of the American Chemical Society · doi:10.1021/ja058364k · Cited by 586
Metadata
- Authors
- Disney, M. D., Zheng, J., Swager, T. M., & Seeberger, P. H.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2004-09-25
- Volume
- 126
- Issue
- 41
- Pages
- 13343-13346
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W1986772160
- Cited by
- 457
- References
- 1
- FWCI
- 12.31
- Type
- journal article
- Language
- en
- Open access
- closed
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- Disney, M. D., Zheng, J., Swager, T. M., & Seeberger, P. H. (2004). Detection of Bacteria with Carbohydrate-Functionalized Fluorescent Polymers. Journal of the American Chemical Society. https://doi.org/10.1021/ja047936i
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