The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
A Chondroitin Sulfate Small Molecule that Stimulates Neuronal Growth
Abstract
Chondroitin sulfate glycosaminoglycans are sulfated polysaccharides involved in cell division, neuronal development, and spinal cord injury. Here, we report the synthesis and identification of a chondroitin sulfate tetrasaccharide that stimulates the growth and differentiation of neurons. These studies represent the first, direct investigations into the structure-activity relationships of chondroitin sulfate using homogeneous synthetic molecules and define a tetrasaccharide as a minimal motif required for activity.
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Citations
Cites
Chondroitinase ABC promotes functional recovery after spinal cord injury
Bradbury, E. J., Moon, L. D. F., Popat, R. J., King, V. R., Bennett, G. S., Patel, P. N., Fawcett, J. W., & McMahon, S. B. (2002) · Nature · doi:10.1038/416636a · Cited by 2,357
Wnt proteins are lipid-modified and can act as stem cell growth factors
Willert, K., Brown, J. D., Danenberg, E., Duncan, A. W., Weissman, I. L., Reya, T., Yates, J. R., & Nusse, R. (2003) · Nature · doi:10.1038/nature01611 · Cited by 2,257
Cited by
Biodegradable Polymer Nanogels for Drug/Nucleic Acid Delivery
Li, Y., Maciel, D., Rodrigues, J., Shi, X., & Tomás, H. (2015) · Chemical Reviews · doi:10.1021/cr500131f · Cited by 478
Contactin-1 is a functional receptor for neuroregulatory chondroitin sulfate-E
Mikami, T., Yasunaga, D., & Kitagawa, H. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m809227200 · Cited by 124
Flexible Roles for Proteoglycan Sulfation and Receptor Signaling
Yu, P., Pearson, C. S., & Geller, H. M. (2018) · Trends in Neurosciences · doi:10.1016/j.tins.2017.10.005 · Cited by 67
Metadata
- Authors
- Tully, S. E., Mabon, R., Gama, C. I., Tsai, S. M., Liu, X., & Hsieh-Wilson, L. C.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2004-06-01
- Volume
- 126
- Issue
- 25
- Pages
- 7736-7737
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2063378545
- Cited by
- 170
- References
- 2
- FWCI
- 2.97
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
