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Rational and Combinatorial Design of Peptide Capping Ligands for Gold Nanoparticles
Abstract
Based on protein folding considerations, a pentapeptide ligand, CALNN, which converts citrate-stabilized gold nanoparticles into extremely stable, water-soluble gold nanoparticles with some chemical properties analogous to those of proteins, has been designed. These peptide-capped gold nanoparticles can be freeze-dried and stored as powders that can be subsequently redissolved to yield stable aqueous dispersions. Filtration, size-exclusion chromatography, ion-exchange chromatography, electrophoresis, and centrifugation can be applied to these particles. The effect of 58 different peptide sequences on the electrolyte-induced aggregation of the nanoparticles was studied. The stabilities conferred by these peptide ligands depended on their length, hydrophobicity, and charge and in some cases resulted in further improved stability compared with CALNN, yielding detailed design criteria for peptide capping ligands. A simple strategy for the introduction of recognition groups is proposed and demonstrated with biotin and Strep-tag II.
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Citations
Cited by
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Laser ablation synthesis in solution and size manipulation of noble metal nanoparticles
Amendola, V., & Meneghetti, M. (2009) · Physical Chemistry Chemical Physics · doi:10.1039/b900654k · Cited by 1,020
Piella, J., Bastús, N. G., & Puntes, V. (2017) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.6b00575 · Cited by 382
Synthesis of Gold Nanoparticles Using Multifunctional Peptides
Slocik, J. M., Stone, M. O., & Naik, R. R. (2005) · Small · doi:10.1002/smll.200500172 · Cited by 339
Microbial synthesis of gold nanoparticles: Current status and future prospects
Shedbalkar, U., Singh, R., Wadhwani, S., Gaidhani, S., & Chopade, B. A. (2014) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2013.12.011 · Cited by 330
Metadata
- Authors
- Lévy, R., Thanh, N. T. K., Doty, R. C., Hussain, I., Nichols, R. J., Schiffrin, D. J., Brust, M., & Fernig, D. G.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2004-07-21
- Volume
- 126
- Issue
- 32
- Pages
- 10076-10084
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2132651708
- Cited by
- 724
- References
- 0
- FWCI
- 12.61
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lévy, R., Thanh, N. T. K., Doty, R. C., Hussain, I., Nichols, R. J., Schiffrin, D. J., Brust, M., & Fernig, D. G. (2004). Rational and Combinatorial Design of Peptide Capping Ligands for Gold Nanoparticles. Journal of the American Chemical Society. https://doi.org/10.1021/ja0487269
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