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Molecular Details of Urease Inhibition by Boric Acid: Insights into the Catalytic Mechanism
Abstract
The structure of the complex of urease, a Ni-containing metalloenzyme, with boric acid was determined at 2.10 A resolution. The complex shows the unprecedented binding mode of the competitive inhibitor to the dinuclear metal center, with the B(OH)3 molecule bridging the Ni ions and leaving in place the bridging hydroxide. Boric acid can be considered a substrate analogue of urea, and the structure supports the proposal that the Ni-bridging hydroxide acts as the nucleophile in the enzymatic process of urea hydrolysis.
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Cited by
Metal ions in biological catalysis: from enzyme databases to general principles
Andreini, C., Bertini, I., Cavallaro, G., Holliday, G. L., & Thornton, J. M. (2008) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s00775-008-0404-5 · Cited by 1,150
Chien, S. H., Prochnow, L. I., & Cantarella, H. (2009) · Advances in Agronomy · doi:10.1016/s0065-2113(09)01008-6 · Cited by 502
Chemistry of Ni2+ in Urease: Sensing, Trafficking, and Catalysis
Zambelli, B., Musiani, F., Benini, S., & Ciurli, S. (2011) · Accounts of Chemical Research · doi:10.1021/ar200041k · Cited by 290
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Metadata
- Authors
- Benini, S., Rypniewski, W. R., Wilson, K. S., Mangani, S., & Ciurli, S.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2004-03-01
- Volume
- 126
- Issue
- 12
- Pages
- 3714-3715
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2000312207
- Cited by
- 172
- References
- 0
- FWCI
- 3.96
- Type
- journal article
- Language
- en
- Open access
- closed
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- Benini, S., Rypniewski, W. R., Wilson, K. S., Mangani, S., & Ciurli, S. (2004). Molecular Details of Urease Inhibition by Boric Acid: Insights into the Catalytic Mechanism. Journal of the American Chemical Society. https://doi.org/10.1021/ja049618p
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