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Controlled Clustering of Superparamagnetic Nanoparticles Using Block Copolymers: Design of New Contrast Agents for Magnetic Resonance Imaging
Open accessAbstract
When polyelectrolyte-neutral block copolymers are mixed in aqueous solutions with oppositely charged species, stable complexes are found to form spontaneously. The mechanism is based on electrostatics and on the compensation between the opposite charges. Electrostatic complexes exhibit a core-shell microstructure. In the core, the polyelectrolyte blocks and the oppositely charged species are tightly bound and form a dense coacervate microphase. The shell is made of the neutral chains and surrounds the core. In this paper, we report on the structural and magnetic properties of such complexes made from 6.3 nm diameter superparamagnetic nanoparticles (maghemite gamma-Fe(2)O(3)) and cationic-neutral copolymers. The copolymers investigated are poly(trimethylammonium ethylacrylate methyl sulfate)-b-poly(acrylamide), with molecular weights 5000-b-30000 g mol(-)(1) and 110000-b-30000 g mol(-)(1). The mixed copolymer-nanoparticle aggregates were characterized by a combination of light scattering and cryo-transmission electron microscopy. Their hydrodynamic diameters were found in the range 70-150 nm, and their aggregation numbers (number of nanoparticles per aggregate) from tens to hundreds. In addition, Magnetic Resonance Spin-Echo measurements show that the complexes have a better contrast in Magnetic Resonance Imaging than single nanoparticles and that these complexes could be used for biomedical applications.
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Cited by
Lee, J. E., Lee, N., Kim, H., Kim, J., Choi, S. H., Kim, J. H., Kim, T., Song, I. C., Park, S. P., Moon, W. K., et al. (2010) · Journal of the American Chemical Society · doi:10.1021/ja905793q · Cited by 707
Sanson, C., Diou, O., Thévenot, J., Ibarboure, E., Soum, A., Brûlet, A., Miraux, S., Thiaudière, E., Tan, S., Brisson, A., et al. (2011) · ACS Nano · doi:10.1021/nn102762f · Cited by 489
Self-citationLee, E. S., Oh, K. T., Kim, D., Youn, Y. S., & Bae, Y. H. (2007) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.08.006 · Cited by 446
Yang, J., Lee, C., Ko, H., Suh, J., Yoon, H., Lee, K., Huh, Y., & Haam, S. (2007) · Angewandte Chemie International Edition · doi:10.1002/anie.200703554 · Cited by 331
Functionalized Magnetite Nanoparticles—Synthesis, Properties, and Bio-Applications
Majewski, P., & Thierry, B. (2007) · Critical Reviews in Solid State and Materials Sciences · doi:10.1080/10408430701776680 · Cited by 289
Metadata
- Authors
- Berret, J.-F., Schonbeck, N., Gazeau, F., El Kharrat, D., Sandre, O., Vacher, A., & Airiau, M.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2006-01-13
- Volume
- 128
- Issue
- 5
- Pages
- 1755-1761
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2095405748
- Cited by
- 361
- References
- 0
- FWCI
- 17.75
- Type
- journal article
- Language
- en
- Open access
- green
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- Berret, J.-F., Schonbeck, N., Gazeau, F., El Kharrat, D., Sandre, O., Vacher, A., & Airiau, M. (2006). Controlled Clustering of Superparamagnetic Nanoparticles Using Block Copolymers: Design of New Contrast Agents for Magnetic Resonance Imaging. Journal of the American Chemical Society. https://doi.org/10.1021/ja0562999
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