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DNA−Gold Nanorod Conjugates for Remote Control of Localized Gene Expression by near Infrared Irradiation
Abstract
Gold nanorods were attached to the gene of enhanced green fluorescence protein (EGFP) for the remote control of gene expression in living cells. The UV-vis spectroscopy, electrophoresis, and transmission electron microscopy (TEM) were used to study the optical and structural properties of the EGFP DNA and gold nanorod (EGFP-GNR) conjugates before and after femto-second near-infrared (NIR) laser irradiation. Upon NIR irradiation, the gold nanorods of EGFP-GNR conjugates underwent shape transformation that resulted in the release of EGFP DNA. When EGFP-GNR conjugates were delivered to cultured HeLa cells, induced GFP expression was specifically observed in cells that were locally exposed to NIR irradiation. Our results demonstrate the feasibility of using gold nanorods and NIR irradiation as means of remote control of gene expression in specific cells. This approach has potential applications in biological and medical studies.
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Cites
A clearer vision for in vivo imaging
Weissleder, R. (2001) · Nature Biotechnology · doi:10.1038/86684 · Cited by 3,839
Cited by
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Liu, Z., Davis, C., Cai, W., He, L., Chen, X., & Dai, H. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707654105 · Cited by 1,116
The importance of nanoparticle shape in cancer drug delivery
Truong, N. P., Whittaker, M. R., Mak, C. W., & Davis, T. P. (2015) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2014.950564 · Cited by 594
Guo, L., Yan, D. D., Yang, D., Li, Y., Wang, X., Zalewski, O., Yan, B., & Lu, W. (2014) · ACS Nano · doi:10.1021/nn5002112 · Cited by 532
Gold Nanoparticles for Nucleic Acid Delivery
Ding, Y., Jiang, Z., Saha, K., Kim, C. S., Kim, S. T., Landis, R. F., & Rotello, V. M. (2014) · Molecular Therapy · doi:10.1038/mt.2014.30 · Cited by 521
Metadata
- Authors
- Chen, C.-C., Lin, Y.-P., Wang, C.-W., Tzeng, H.-C., Wu, C.-H., Chen, Y.-C., Chen, C.-P., Chen, L.-C., & Wu, Y.-C.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2006-02-24
- Volume
- 128
- Issue
- 11
- Pages
- 3709-3715
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2044560021
- Cited by
- 424
- References
- 1
- FWCI
- 14.11
- Type
- journal article
- Language
- en
- Open access
- closed
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- Chen, C.-C., Lin, Y.-P., Wang, C.-W., Tzeng, H.-C., Wu, C.-H., Chen, Y.-C., Chen, C.-P., Chen, L.-C., & Wu, Y.-C. (2006). DNA−Gold Nanorod Conjugates for Remote Control of Localized Gene Expression by near Infrared Irradiation. Journal of the American Chemical Society. https://doi.org/10.1021/ja0570180
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