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Development of a Ratiometric Fluorescent Zinc Ion Probe in Near-Infrared Region, Based on Tricarbocyanine Chromophore
Abstract
Novel ratiometric fluorescent probes for Zn2+ in the near-infrared region, based on a tricarbocyanine chromophore, have been designed, synthesized, and evaluated. Upon addition of Zn2+, a 44 nm red shift of the absorption maximum was observed, which indicates that this probe could work as a ratiometric probe for Zn2+. This change is due to the difference in the electron-donating ability of the amine substituent before and after reaction with Zn2+. This fluorescence modulation of amine-substituted tricarbocyanines should be applicable to dual-wavelength measurement of various biomolecules or enzyme activities.
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Weissleder, R. (2001) · Nature Biotechnology · doi:10.1038/86684 · Cited by 3,839
Cited by
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Lee, M. H., Kim, J. S., & Sessler, J. L. (2015) · Chemical Society Reviews · doi:10.1039/c4cs00280f · Cited by 1,642
Synthetic fluorescent sensors for studying the cell biology of metals
Domaille, D. W., Que, E. L., & Chang, C. J. (2008) · Nature Chemical Biology · doi:10.1038/nchembio.69 · Cited by 1,081
Metadata
- Authors
- Kiyose, K., Kojima, H., Urano, Y., & Nagano, T.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2006-04-29
- Volume
- 128
- Issue
- 20
- Pages
- 6548-6549
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2071584476
- Cited by
- 337
- References
- 1
- FWCI
- 11.10
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kiyose, K., Kojima, H., Urano, Y., & Nagano, T. (2006). Development of a Ratiometric Fluorescent Zinc Ion Probe in Near-Infrared Region, Based on Tricarbocyanine Chromophore. Journal of the American Chemical Society. https://doi.org/10.1021/ja060399c
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